Atlas One · Host Biology · Scale 07 — System

Glioblastoma

Most aggressive primary brain tumor; IDH-wildtype GBM has EGFRvIII amplification (~40%), PTEN loss (~30%), and TERT promoter mutations. Temozolomide + radiotherapy is standard; tumor-treating fields (TTFields) improve OS; MGMT promoter methylation predicts temozolomide benefit.

Also known as: GBM, glioblastoma multiforme, WHO grade 4 glioma, IDH-wildtype glioblastoma, GBM IDH-wt, high-grade glioma

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
glioblastoma

Glioblastoma

Most aggressive primary brain tumor; IDH-wildtype GBM has EGFRvIII amplification (~40%), PTEN loss (~30%), and TERT promoter mutations. Temozolomide + radiotherapy is standard; tumor-treating fields (TTFields) improve OS; MGMT promoter methylation predicts temozolomide benefit.

Entry Metadata

FieldValue
IDglioblastoma
NameGlioblastoma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toEgfr connects-toPten connects-toHif 1Alpha connects-toTert connects-toIdh1 connects-toNf1 connects-toVegf connects-toDiffuse Midline Glioma connects-toBrain connects-toMicroglia connects-toAstrocyte connects-toIdh Mutant Glioma connects-toMeningioma connects-toPhoton connects-toNeuron connects-toLi Fraumeni Syndrome connects-toOligodendrocyte connects-toP53 connects-toEpilepsy connects-toNervous System connects-toCdkn2A connects-toEndothelial Cell connects-toSynapse connects-toMacrophage connects-toGlutamate connects-toRegulatory T Cell connects-toPdgf connects-toCdk4 6 connects-toOxygen connects-toCalcium connects-toT Cytotoxic Cell connects-toProton connects-toAquaporin 4 connects-toPotassium connects-toIron connects-toFibroblast connects-toBone Marrow connects-toElectron connects-toLung connects-toEye connects-toAntibody connects-toNeutrophil connects-toAdrenal Gland connects-toVenous Thromboembolism connects-toStat3 connects-toDendritic Cell connects-toMtor connects-toNatural Killer Cell connects-toLynch Syndrome connects-toAtrx connects-toNf Kb connects-toStroke connects-toNlrp3 Inflammasome connects-toMajor Depressive Disorder connects-toSepsis connects-toPneumocystis Jirovecii connects-toAnemia Of Chronic Disease connects-toCkd connects-toType 2 Diabetes connects-toAspergillus Fumigatus connects-toWound Healing connects-toEndocrine System connects-toDigestive System connects-toGeneralized Anxiety Disorder connects-toImmune System connects-toIntegumentary System connects-toMusculoskeletal System connects-toCardiovascular System connects-toRespiratory System connects-toReproductive System connects-toCancer Chemotherapy connects-toTargeted Therapy connects-toCheckpoint Inhibitors connects-toCar T connects-toAxonal Transport connects-toPancreatic Cancer connects-toCowden Syndrome connects-toBdnf connects-toHippocampus connects-toNeurofibromatosis Type 1 connects-toArterial Wall connects-toMedulloblastoma connects-toMet connects-toNotch connects-toAkt connects-toMyc connects-toCyclin D1 connects-toEzh2 connects-toCcl2 connects-toTgf Beta connects-toErk1 2 connects-toCxcl12 connects-toCgas Sting connects-toRad51 connects-toCalcium connects-toDnmt3A connects-toPerforin connects-toPik3Ca connects-toRb1 connects-toMdm2 connects-toKras connects-toJak1 2 connects-toNfe2L2 connects-toGalectin 3 connects-toSmad4 connects-toStat1 connects-toFoxo connects-toGsk 3B connects-toSrc Kinase connects-toS100A8 A9 connects-toWnt Beta Catenin connects-toAutophagy connects-toAmpk connects-toArid1A connects-toIl 6 connects-toCcr5 connects-toYap1 connects-toCalcineurin connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toAdenosine connects-toOsteopontin connects-toMhc Class Ii connects-toIl 2 connects-toPd 1 connects-toGlucocorticoid Receptor connects-toIl 10 connects-toGaba connects-toIl 4 connects-toProstaglandins connects-toXanthine Oxidase connects-toIl 13 connects-toAcetylcholine connects-toMagnesium connects-toCholesterol connects-toSerotonin connects-toNorepinephrine connects-toIfn Gamma connects-toType I Interferon connects-toIl 12 connects-toLeptin connects-toAdiponectin connects-toResistin connects-toIl 5 connects-toIl 23 connects-toIge connects-toC5Ar1 connects-toT Helper Cell connects-toMast Cell connects-toComplement C5 connects-toFactor H connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toC1 Esterase Inhibitor connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toTestosterone connects-toSelenium connects-toIodine connects-toSodium connects-toCopper connects-toZinc connects-toPhosphorus connects-toChloride connects-toNitrogen connects-toCarbon connects-toHydrogen connects-toSulfur connects-toGlp 1 connects-toAngiotensin Ii connects-toRankl connects-toFibronectin connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toAdrenomedullin connects-toFgfr connects-toEpinephrine connects-toRenin connects-toMyostatin connects-toAngiopoietin