Atlas One · Host Biology · Scale 03 — Molecular

RB1

Cell cycle gatekeeper; CDK4/6-cyclin D phosphorylates RB → E2F release → S phase entry. Biallelic RB1 loss causes retinoblastoma and SCLC; also lost in NEPC, osteosarcoma, and bladder cancer; CDK4/6 inhibitors (palbociclib) restore RB pathway function in RB-intact tumors.

Also known as: RB, retinoblastoma protein, pRb, p110-RB, retinoblastoma tumor suppressor, RB pocket protein, E2F repressor

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
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rb1

RB1

Cell cycle gatekeeper; CDK4/6-cyclin D phosphorylates RB → E2F release → S phase entry. Biallelic RB1 loss causes retinoblastoma and SCLC; also lost in NEPC, osteosarcoma, and bladder cancer; CDK4/6 inhibitors (palbociclib) restore RB pathway function in RB-intact tumors.

Entry Metadata

FieldValue
IDrb1
NameRB1
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toCdk4 6 connects-toP53 connects-toMyc connects-toHif 1Alpha

Sources