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hif-1alpha
HIF-1alpha
Oxygen-regulated transcription factor; stabilized when PHDs are inactivated by low O₂ → escapes pVHL-mediated degradation. Drives VEGF, EPO, and glycolytic gene expression; central to cancer metabolism (Warburg effect), angiogenesis, and ischemic adaptation.
Entry Metadata
| Field | Value |
|---|---|
| ID | hif-1alpha |
| Name | HIF-1alpha |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Semenza GL. HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell. 2001;107(1):1-3. · PubMed 11595178
- Kaelin WG Jr, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell. 2008;30(4):393-402. · PubMed 18498744
- Semenza GL. Hypoxia-inducible factors in physiology and medicine. Cell. 2012;148(3):399-408. · PubMed 22304911