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vegf
VEGF
Primary angiogenic cytokine; VEGF-A binds VEGFR-2 on endothelial cells triggering proliferation, migration, and tube formation. Upregulated by HIF-1α in hypoxia; targeted by bevacizumab in metastatic cancer and ranibizumab in neovascular macular degeneration.
Entry Metadata
| Field | Value |
|---|---|
| ID | vegf |
| Name | VEGF |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003;9(6):669-676. · PubMed 12778165
- Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004;350(23):2335-2342. · PubMed 15175435
- Brown DM, Kaiser PK, Michels M, et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med. 2006;355(14):1432-1444. · PubMed 17021319