Atlas One · Host Biology · Scale 07 — System

Lynch Syndrome

Lynch syndrome is the most common inherited cancer predisposition syndrome; germline MMR gene mutations (MLH1, MSH2, MSH6, PMS2) → MSI-H tumors; CRC lifetime risk ~40-80%; pembrolizumab/dostarlimab FDA-approved for dMMR tumors; universal tumor MMR testing recommended.

Also known as: Lynch syndrome, HNPCC, hereditary nonpolyposis colorectal cancer, MMR Lynch, dMMR Lynch, MLH1 Lynch, MSH2 Lynch, MSI-H Lynch, Lynch colon cancer, Lynch endometrial

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
lynch-syndrome

Lynch Syndrome

Lynch syndrome is the most common inherited cancer predisposition syndrome; germline MMR gene mutations (MLH1, MSH2, MSH6, PMS2) → MSI-H tumors; CRC lifetime risk ~40-80%; pembrolizumab/dostarlimab FDA-approved for dMMR tumors; universal tumor MMR testing recommended.

Entry Metadata

FieldValue
IDlynch-syndrome
NameLynch Syndrome
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toMsh2 connects-toMlh1 connects-toPd 1 connects-toColorectal Cancer connects-toEndometrial Cancer connects-toGastric Cancer connects-toLarge Intestine connects-toJuvenile Polyposis Syndrome connects-toFap connects-toT Cytotoxic Cell connects-toOvarian Cancer connects-toBladder Cancer connects-toImmune System

Sources