Atlas One · Host Biology · Scale 07 — System

Lynch Syndrome

Lynch syndrome is the most common inherited cancer predisposition syndrome; germline MMR gene mutations (MLH1, MSH2, MSH6, PMS2) → MSI-H tumors; CRC lifetime risk ~40-80%; pembrolizumab/dostarlimab FDA-approved for dMMR tumors; universal tumor MMR testing recommended.

Also known as: Lynch syndrome, HNPCC, hereditary nonpolyposis colorectal cancer, MMR Lynch, dMMR Lynch, MLH1 Lynch, MSH2 Lynch, MSI-H Lynch, Lynch colon cancer, Lynch endometrial

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
lynch-syndrome

Lynch Syndrome

Lynch syndrome is the most common inherited cancer predisposition syndrome; germline MMR gene mutations (MLH1, MSH2, MSH6, PMS2) → MSI-H tumors; CRC lifetime risk ~40-80%; pembrolizumab/dostarlimab FDA-approved for dMMR tumors; universal tumor MMR testing recommended.

Entry Metadata

FieldValue
IDlynch-syndrome
NameLynch Syndrome
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toMsh2 connects-toMlh1 connects-toPd 1 connects-toColorectal Cancer connects-toEndometrial Cancer connects-toGastric Cancer connects-toLarge Intestine connects-toJuvenile Polyposis Syndrome connects-toFap connects-toT Cytotoxic Cell connects-toOvarian Cancer connects-toBladder Cancer connects-toImmune System connects-toPancreatic Cancer connects-toCholangiocarcinoma connects-toGlioblastoma connects-toSkin connects-toSmall Intestine connects-toWnt Beta Catenin connects-toDigestive System connects-toReproductive System connects-toIntegumentary System connects-toKidney connects-toProstate Cancer connects-toDendritic Cell connects-toBraf connects-toNatural Killer Cell connects-toB Cell connects-toTgf Beta connects-toBrain connects-toRegulatory T Cell connects-toIron connects-toIntestinal Epithelium connects-toMacrophage connects-toPhoton connects-toStomach connects-toNeuron connects-toElectron connects-toLiver connects-toBone Marrow connects-toAntibody connects-toErythrocyte connects-toPancreas connects-toPlatelet connects-toPlasma Cell connects-toKras connects-toCtla 4 connects-toHereditary Breast Ovarian Cancer connects-toAstrocyte connects-toIron Deficiency Anemia connects-toVenous Thromboembolism connects-toSepsis connects-toStat3 connects-toNf Kb connects-toAnemia Of Chronic Disease connects-toCkd connects-toHeart Failure connects-toMajor Depressive Disorder connects-toGeneralized Anxiety Disorder connects-toNeuropathic Pain connects-toAspergillus Fumigatus connects-toRenal System connects-toWound Healing connects-toEndocrine System connects-toNervous System connects-toRespiratory System connects-toMusculoskeletal System connects-toAspirin connects-toDietary Fiber connects-toCardiovascular System connects-toCheckpoint Inhibitors connects-toCancer Chemotherapy connects-toLi Fraumeni Syndrome connects-toMutyh Associated Polyposis connects-toOvarian Clear Cell Carcinoma connects-toGerminal Center connects-toMedulloblastoma connects-toAll connects-toHepatic Lobule connects-toNeurofibromatosis Type 1 connects-toPeutz Jeghers Syndrome connects-toCowden Syndrome connects-toP53 connects-toPik3Ca connects-toTert connects-toAkt connects-toMyc connects-toHif 1Alpha connects-toIfn Gamma connects-toCdkn2A connects-toCcl2 connects-toCgas Sting connects-toPerforin connects-toCxcl12 connects-toProstaglandins connects-toEstrogen connects-toImmunoglobulin G connects-toErk1 2 connects-toMtor connects-toApc connects-toJak1 2 connects-toMyd88 connects-toRb1 connects-toSmad4 connects-toGalectin 3 connects-toPten connects-toStat1 connects-toCdk4 6 connects-toFoxo connects-toMdm2 connects-toS100A8 A9 connects-toGsk 3B connects-toSrc Kinase connects-toDnmt3A connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toIl 1B connects-toIl 33 connects-toIl 6 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toMhc Class Ii connects-toIl 2 connects-toIl 12 connects-toHemoglobin connects-toT Helper Cell connects-toIl 10 connects-toIl 4 connects-toCholesterol connects-toXanthine Oxidase connects-toIl 13 connects-toLeptin connects-toCalcium connects-toAdiponectin connects-toResistin connects-toType I Interferon connects-toIl 5 connects-toIl 23 connects-toHistamine connects-toMast Cell connects-toNeutrophil connects-toIge connects-toComplement C5 connects-toVitamin D connects-toSelenium connects-toC5Ar1 connects-toFactor H connects-toTransferrin connects-toTslp connects-toPeriostin connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toErythropoietin connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toZinc connects-toPotassium connects-toPhosphorus connects-toCarbon connects-toChloride connects-toNitrogen connects-toHydrogen connects-toOxygen connects-toSulfur connects-toGlp 1 connects-toAngiotensin Ii connects-toRankl connects-toVegf connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf

Sources