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bone-marrow
Bone Marrow
Haematopoietic tissue filling the medullary cavity of flat bones and the epiphyses of long bones. Produces all blood cell lineages from multipotent haematopoietic stem cells (HSCs) at ~500 billion cells/day. Red marrow active; yellow marrow (fat) increases with age.
Entry Metadata
| Field | Value |
|---|---|
| ID | bone-marrow |
| Name | Bone Marrow |
| Status | draft |
| Last reviewed | 2026-06-05 |
| Atlas | 01-human |
| Scale | 05-tissue |
Cross-Atlas Connections
part-ofImmune System
part-ofCardiovascular System
containsErythrocyte
containsB Cell
containsMacrophage
part-ofHuman Body
composed-ofHemoglobin
modulated-byErythropoietin
modulated-byPhosphorus
part-ofMusculoskeletal System
modulated-byCortical Bone
composed-ofNeutrophil
composed-ofOsteoblast
composed-ofOsteoclast
composed-ofPlatelet
modulated-byCxcl12
connects-toPnh
connects-toGvhd
connects-toAplastic Anemia
connects-toThrombopoietin
Sources
- Orkin SH, Zon LI. Hematopoiesis: an evolving paradigm for stem cell biology. Cell. 2008;132(4):631-44. · PubMed 18295580
- Morrison SJ, Scadden DT. The bone marrow niche for haematopoietic stem cells. Nature. 2014;505(7483):327-34. · PubMed 24429631
- Short NJ, Kantarjian H. Bone marrow anatomy and its role in haematopoiesis. Best Pract Res Clin Haematol. 2021;34(1):101249. · PubMed 33762083
- Hall JE. Guyton and Hall Textbook of Medical Physiology. 14th ed. Elsevier; 2021. Ch. 32.