Thrombopoietin

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thrombopoietin

Thrombopoietin (TPO; THPO, chr3q27.3) is the master regulator of megakaryopoiesis; binds c-Mpl → JAK2/STAT5 → platelet production. Levels inversely correlate with platelet count via Mpl absorption. TPO-receptor agonists (romiplostim, eltrombopag) treat ITP and aplastic anemia.

Entry Metadata

Field	Value
ID	thrombopoietin
Name	Thrombopoietin
Status	draft
Last reviewed	2026-06-07
Atlas	01-human
Scale	03-molecular

Cross-Atlas Connections

modulatesPlatelet connects-toImmune Thrombocytopenia connects-toFcrn connects-toMyelofibrosis connects-toAplastic Anemia connects-toBone Marrow

Sources

de Sauvage FJ, Hass PE, Spencer SD, et al. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature. 1994;369(6481):533-538. · PubMed 8202154
Bussel JB, Kuter DJ, George JN, et al. AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP. N Engl J Med. 2006;355(16):1672-1681. · PubMed 17050891
Cheng G, Saleh MN, Marcher C, et al. Eltrombopag for management of chronic immune thrombocytopenia (RAISE): a 6-month, randomised, phase 3 study. Lancet. 2011;377(9763):393-402. · PubMed 21237459
Kuter DJ. The biology of thrombopoietin and thrombopoietin receptor agonists. Int J Hematol. 2013;98(1):10-23. · PubMed 23821195