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myelofibrosis
Myelofibrosis
Myelofibrosis is a MPN with BM fibrosis, megakaryocyte dysplasia, and splenomegaly; drivers JAK2 V617F ~60%, CALR exon 9 ~20-25%, MPL ~8%; ruxolitinib (COMFORT-I/II), fedratinib, pacritinib, momelotinib (MOMENTUM) approved; allo-SCT is the only curative option.
Entry Metadata
| Field | Value |
|---|---|
| ID | myelofibrosis |
| Name | Myelofibrosis |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toCalr
connects-toJak2
connects-toJak1 2
connects-toTgf Beta
connects-toThrombopoietin
connects-toBone Marrow
connects-toSpleen
connects-toMyeloproliferative Neoplasms
connects-toMds
connects-toPolycythemia Vera
connects-toErythrocyte
connects-toEssential Thrombocythemia
connects-toAml
connects-toFibroblast
connects-toCml
connects-toGout
connects-toLiver
connects-toFibrosis
connects-toMpl
connects-toErythropoietin
connects-toPlatelet
connects-toCollagen
connects-toImmune System
connects-toPdgf
connects-toT Cytotoxic Cell
connects-toAnemia Of Chronic Disease
connects-toIl 6
connects-toHepatocyte
connects-toMacrophage
connects-toIron
connects-toHeart
connects-toNeutrophil
connects-toPhoton
connects-toOsteoblast
connects-toLung
connects-toElectron
connects-toCalcium
connects-toKidney
connects-toVegf
connects-toAlbumin
connects-toVenous Thromboembolism
connects-toPhosphorus
connects-toLarge Intestine
connects-toNeuron
connects-toEndothelial Cell
connects-toNf Kb
connects-toPulmonary Arterial Hypertension
connects-toCxcl12
connects-toMast Cell
connects-toSepsis
connects-toStat3
connects-toAtherosclerosis
connects-toStroke
connects-toTuberculosis
connects-toAspergillus Fumigatus
connects-toHeart Failure
connects-toVaricella Zoster Virus
connects-toPneumocystis Jirovecii
connects-toMajor Depressive Disorder
connects-toDigestive System
connects-toEndocrine System
connects-toGeneralized Anxiety Disorder
connects-toMusculoskeletal System
connects-toNervous System
connects-toIntegumentary System
connects-toLymphatic System
connects-toRespiratory System
connects-toRenal System
connects-toTargeted Therapy
connects-toAspirin
connects-toReproductive System
connects-toCancer Chemotherapy
connects-toCortical Bone
connects-toAplastic Anemia
connects-toHepatic Lobule
connects-toArterial Wall
connects-toLeishmaniasis
connects-toGvhd
connects-toAlveolus
connects-toBreast Cancer
connects-toVon Willebrand Factor
connects-toInherited Thrombophilia
connects-toPeripheral Nerve
connects-toType I Interferon
connects-toEzh2
connects-toHif 1Alpha
connects-toIl 1B
connects-toTnf Alpha
connects-toOsteopontin
connects-toPf4
connects-toBcl 2
connects-toRankl
connects-toSf3B1
connects-toFgfr
connects-toS100A8 A9
connects-toErk1 2
connects-toDnmt3A
connects-toNlrp3 Inflammasome
connects-toSmad4
connects-toAkt
connects-toP53
connects-toMtor
connects-toRunx1
connects-toIdh1
connects-toGalectin 3
connects-toStat1
connects-toCgas Sting
connects-toFoxo
connects-toGsk 3B
connects-toCdk4 6
connects-toPerforin
connects-toMdm2
connects-toSrc Kinase
connects-toPik3Ca
connects-toAutophagy
connects-toAmpk
connects-toCcr5
connects-toArid1A
connects-toIl 33
connects-toIl 17A
connects-toComplement C3
connects-toCalcineurin
connects-toActivin A
connects-toSclerostin
connects-toHepcidin
connects-toHemoglobin
connects-toAngiopoietin
connects-toXanthine Oxidase
connects-toFerroportin
connects-toIl 10
connects-toNitric Oxide
connects-toIl 4
connects-toLeptin
connects-toAdiponectin
connects-toIl 13
connects-toResistin
connects-toZinc
connects-toMacrophage
connects-toAml
connects-toIron
connects-toNatural Killer Cell
connects-toIfn Gamma
connects-toIl 12
connects-toIl 5
connects-toIl 23
connects-toIge
connects-toT Helper Cell
connects-toComplement C5
connects-toC5Ar1
connects-toFactor H
connects-toTransferrin
connects-toPeriostin
connects-toTslp
connects-toBradykinin
connects-toC1 Esterase Inhibitor
connects-toHistamine
connects-toMelatonin
connects-toProlactin
connects-toTestosterone
connects-toSerotonin
connects-toOxytocin
connects-toVasopressin
connects-toSelenium
connects-toIodine
connects-toMagnesium
connects-toCopper
connects-toSodium
connects-toPotassium
connects-toChloride
connects-toCarbon
connects-toHydrogen
connects-toNitrogen
connects-toOxygen
connects-toSulfur
connects-toPd 1
connects-toGlp 1
connects-toAngiotensin Ii
connects-toWnt Beta Catenin
connects-toIl 2
connects-toFibronectin
connects-toNotch
connects-toIgf 1
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAldosterone
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toBdnf
connects-toEpinephrine
connects-toRenin
Sources
- Verstovsek S, Mesa RA, Gotlib J, et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med. 2012;366(9):799-807. · PubMed 22375971
- Harrison C, Kiladjian JJ, Al-Ali HK, et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med. 2012;366(9):787-798. · PubMed 22375970