Atlas One · Host Biology · Scale 07 — System

Myelofibrosis

Myelofibrosis is a MPN with BM fibrosis, megakaryocyte dysplasia, and splenomegaly; drivers JAK2 V617F ~60%, CALR exon 9 ~20-25%, MPL ~8%; ruxolitinib (COMFORT-I/II), fedratinib, pacritinib, momelotinib (MOMENTUM) approved; allo-SCT is the only curative option.

Also known as: myelofibrosis, MF, PMF, primary myelofibrosis, post-ET MF, post-PV MF, myeloproliferative neoplasm fibrosis, JAK inhibitor myelofibrosis

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
myelofibrosis

Myelofibrosis

Myelofibrosis is a MPN with BM fibrosis, megakaryocyte dysplasia, and splenomegaly; drivers JAK2 V617F ~60%, CALR exon 9 ~20-25%, MPL ~8%; ruxolitinib (COMFORT-I/II), fedratinib, pacritinib, momelotinib (MOMENTUM) approved; allo-SCT is the only curative option.

Entry Metadata

FieldValue
IDmyelofibrosis
NameMyelofibrosis
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toCalr connects-toJak2 connects-toJak1 2 connects-toTgf Beta connects-toThrombopoietin connects-toBone Marrow connects-toSpleen connects-toMyeloproliferative Neoplasms connects-toMds connects-toPolycythemia Vera connects-toErythrocyte connects-toEssential Thrombocythemia connects-toAml connects-toFibroblast connects-toCml connects-toGout connects-toLiver connects-toFibrosis connects-toMpl connects-toErythropoietin connects-toPlatelet connects-toCollagen connects-toImmune System connects-toPdgf connects-toT Cytotoxic Cell connects-toAnemia Of Chronic Disease connects-toIl 6 connects-toHepatocyte connects-toMacrophage connects-toIron connects-toHeart connects-toNeutrophil connects-toPhoton connects-toOsteoblast connects-toLung connects-toElectron connects-toCalcium connects-toKidney connects-toVegf connects-toAlbumin connects-toVenous Thromboembolism connects-toPhosphorus connects-toLarge Intestine connects-toNeuron connects-toEndothelial Cell connects-toNf Kb connects-toPulmonary Arterial Hypertension connects-toCxcl12 connects-toMast Cell connects-toSepsis connects-toStat3 connects-toAtherosclerosis connects-toStroke connects-toTuberculosis connects-toAspergillus Fumigatus connects-toHeart Failure connects-toVaricella Zoster Virus connects-toPneumocystis Jirovecii connects-toMajor Depressive Disorder connects-toDigestive System connects-toEndocrine System connects-toGeneralized Anxiety Disorder connects-toMusculoskeletal System connects-toNervous System connects-toIntegumentary System connects-toLymphatic System connects-toRespiratory System connects-toRenal System connects-toTargeted Therapy connects-toAspirin connects-toReproductive System connects-toCancer Chemotherapy connects-toCortical Bone connects-toAplastic Anemia connects-toHepatic Lobule connects-toArterial Wall connects-toLeishmaniasis connects-toGvhd connects-toAlveolus connects-toBreast Cancer connects-toVon Willebrand Factor connects-toInherited Thrombophilia connects-toPeripheral Nerve connects-toType I Interferon connects-toEzh2 connects-toHif 1Alpha connects-toIl 1B connects-toTnf Alpha connects-toOsteopontin connects-toPf4 connects-toBcl 2 connects-toRankl connects-toSf3B1 connects-toFgfr connects-toS100A8 A9 connects-toErk1 2 connects-toDnmt3A connects-toNlrp3 Inflammasome connects-toSmad4 connects-toAkt connects-toP53 connects-toMtor connects-toRunx1 connects-toIdh1 connects-toGalectin 3 connects-toStat1 connects-toCgas Sting connects-toFoxo connects-toGsk 3B connects-toCdk4 6 connects-toPerforin connects-toMdm2 connects-toSrc Kinase connects-toPik3Ca connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toActivin A connects-toSclerostin connects-toHepcidin connects-toHemoglobin connects-toAngiopoietin connects-toXanthine Oxidase connects-toFerroportin connects-toIl 10 connects-toNitric Oxide connects-toIl 4 connects-toLeptin connects-toAdiponectin connects-toIl 13 connects-toResistin connects-toZinc connects-toMacrophage connects-toAml connects-toIron connects-toNatural Killer Cell connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toT Helper Cell connects-toComplement C5 connects-toC5Ar1 connects-toFactor H connects-toTransferrin connects-toPeriostin connects-toTslp connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toHistamine connects-toMelatonin connects-toProlactin connects-toTestosterone connects-toSerotonin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toMagnesium connects-toCopper connects-toSodium connects-toPotassium connects-toChloride connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toOxygen connects-toSulfur connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toEpinephrine connects-toRenin