Atlas One · Host Biology · Scale 03 — Molecular

Osteopontin

Osteopontin (OPN/SPP1) is a phosphoprotein DAMPs secreted by macrophages, osteoclasts, and tubular epithelium; integrin αvβ3/CD44 → NF-κB → fibrosis and inflammation; urinary OPN is a CKD progression biomarker; OPN promotes kidney stone formation and renal tubular repair.

Also known as: osteopontin, OPN, SPP1, secreted phosphoprotein 1, bone sialoprotein-1, eta-1, urinary OPN, CD44 ligand

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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osteopontin

Osteopontin

Osteopontin (OPN/SPP1) is a phosphoprotein DAMPs secreted by macrophages, osteoclasts, and tubular epithelium; integrin αvβ3/CD44 → NF-κB → fibrosis and inflammation; urinary OPN is a CKD progression biomarker; OPN promotes kidney stone formation and renal tubular repair.

Entry Metadata

FieldValue
IDosteopontin
NameOsteopontin
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toCkd connects-toTgf Beta connects-toOsteoclast connects-toMultiple Sclerosis

Sources