Atlas One · Host Biology · Scale 04 — Cellular

Osteoclast

Large multinucleated haematopoietic cells (monocyte lineage) that resorb bone via ruffled-border V-ATPase acidification and cathepsin K collagenolysis. RANK-RANKL-OPG axis and NFATc1 govern differentiation; key targets in osteoporosis, RA bone erosion, and Paget disease.

Also known as: bone-resorbing cell, multinucleated giant cell, resorption lacuna cell, tartrate-resistant acid phosphatase positive cell, TRAP+ cell

Scale 04 — CellularScale
draftStatus
2026-06-05Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
osteoclast

Osteoclast

Large multinucleated haematopoietic cells (monocyte lineage) that resorb bone via ruffled-border V-ATPase acidification and cathepsin K collagenolysis. RANK-RANKL-OPG axis and NFATc1 govern differentiation; key targets in osteoporosis, RA bone erosion, and Paget disease.

Entry Metadata

FieldValue
IDosteoclast
NameOsteoclast
Statusdraft
Last reviewed2026-06-05
Atlas01-human
Scale04-cellular

Cross-Atlas Connections

part-ofBone Marrow modulatesImmune System modulatesMacrophage modulatesIl 6 modulated-byRankl modulated-bySclerostin connects-toProton

Sources