Atlas One · Host Biology · Scale 03 — Molecular

RANKL

RANKL (TNFSF11, chr13q14) is a TNF family ligand driving osteoclastogenesis; RANK → TRAF6 → NF-κB → NFATc1 → osteoclast differentiation; OPG is the decoy receptor; denosumab (anti-RANKL) reduces vertebral fractures 68% (FREEDOM) and prevents bone metastasis skeletal events.

Also known as: RANKL, TNFSF11, TRANCE, ODF, OPGL, SOFA, CD254, osteoclast differentiation factor

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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rankl

RANKL

RANKL (TNFSF11, chr13q14) is a TNF family ligand driving osteoclastogenesis; RANK → TRAF6 → NF-κB → NFATc1 → osteoclast differentiation; OPG is the decoy receptor; denosumab (anti-RANKL) reduces vertebral fractures 68% (FREEDOM) and prevents bone metastasis skeletal events.

Entry Metadata

FieldValue
IDrankl
NameRANKL
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toOsteoporosis connects-toOsteoclast connects-toMultiple Myeloma connects-toAnkylosing Spondylitis connects-toBreast Cancer connects-toSclerostin

Sources