Atlas One · Host Biology · Scale 07 — System

Ankylosing Spondylitis

Ankylosing spondylitis (AS; radiographic axSpA) is a chronic inflammatory spondyloarthropathy with sacroiliitis and spinal ankylosis; HLA-B27+ in ~90%; IL-17A/IL-23 and TNF pathways drive enthesitis; anti-TNF and anti-IL-17A (secukinumab, ixekizumab) are first-line therapy.

Also known as: AS, ankylosing spondylitis, axial spondyloarthritis, axSpA, radiographic axSpA, r-axSpA, non-radiographic axSpA, nr-axSpA, Bechterew disease, Marie-Strümpell disease, spondyloarthropathy, SpA, BASDAI, ASDAS, bamboo spine

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
ankylosing-spondylitis

Ankylosing Spondylitis

Ankylosing spondylitis (AS; radiographic axSpA) is a chronic inflammatory spondyloarthropathy with sacroiliitis and spinal ankylosis; HLA-B27+ in ~90%; IL-17A/IL-23 and TNF pathways drive enthesitis; anti-TNF and anti-IL-17A (secukinumab, ixekizumab) are first-line therapy.

Entry Metadata

FieldValue
IDankylosing-spondylitis
NameAnkylosing Spondylitis
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toHla B27 connects-toIl 17A connects-toRankl connects-toTnf Alpha connects-toPsoriatic Arthritis connects-toEye connects-toInflammatory Bowel Disease connects-toIl 23 connects-toPsoriasis connects-toMusculoskeletal System connects-toOsteoblast connects-toOsteoporosis connects-toCardiovascular System connects-toIga Nephropathy connects-toRheumatoid Arthritis connects-toT Helper Cell connects-toGout connects-toFibroblast connects-toHeart connects-toLung connects-toGut Microbiome connects-toCollagen connects-toCalcium connects-toWnt Beta Catenin connects-toT Cytotoxic Cell connects-toJak1 2 connects-toSclerostin connects-toVitamin D connects-toDendritic Cell connects-toLarge Intestine connects-toOsteoclast connects-toMacrophage connects-toBone Marrow connects-toPhoton connects-toPhosphorus connects-toKidney connects-toFibrosis connects-toSkin connects-toNeuron connects-toErythrocyte connects-toLiver connects-toAntibody connects-toCardiomyocyte connects-toReproductive System connects-toProstaglandins connects-toMast Cell connects-toAtherosclerosis connects-toIl 6 connects-toRegulatory T Cell connects-toHeart Failure connects-toStat3 connects-toNf Kb connects-toVenous Thromboembolism connects-toTuberculosis connects-toAnemia Of Chronic Disease connects-toCkd connects-toStroke connects-toHepatitis B Virus connects-toMajor Depressive Disorder connects-toRespiratory System connects-toVaricella Zoster Virus connects-toGeneralized Anxiety Disorder connects-toNervous System connects-toImmune System connects-toRenal System connects-toDigestive System connects-toIntegumentary System connects-toEndocrine System connects-toAdalimumab connects-toIbuprofen connects-toCorticosteroids connects-toTargeted Therapy connects-toCortical Bone connects-toArterial Wall connects-toMultiple Sclerosis connects-toIntestinal Epithelium connects-toFibromyalgia connects-toCardiac Conduction System connects-toAlveolus connects-toGlomerulus connects-toEndocardium connects-toAspergillus Fumigatus connects-toPeripheral Nerve connects-toTgf Beta connects-toVegf connects-toCcl2 connects-toIl 1B connects-toNlrp3 Inflammasome connects-toIfn Gamma connects-toS100A8 A9 connects-toTlr4 connects-toOsteopontin connects-toIl 33 connects-toLeptin connects-toSubstance P connects-toFgfr connects-toPdgf connects-toIl 12 connects-toMyd88 connects-toCgrp connects-toIl 10 connects-toMtor connects-toAkt connects-toPerforin connects-toStat1 connects-toSmad4 connects-toGalectin 3 connects-toErk1 2 connects-toFoxo connects-toHif 1Alpha connects-toGsk 3B connects-toCgas Sting connects-toSrc Kinase connects-toPik3Ca connects-toAmpk connects-toAutophagy connects-toCcr5 connects-toDnmt3A connects-toCxcl12 connects-toArid1A connects-toCalcineurin connects-toComplement C3 connects-toNitric Oxide connects-toSecretory Iga connects-toAngiopoietin connects-toHemoglobin connects-toTroponin Complex connects-toMhc Class Ii connects-toCholesterol connects-toXanthine Oxidase connects-toAdiponectin connects-toHepcidin connects-toIron connects-toInsulin connects-toIl 4 connects-toIl 13 connects-toSmall Intestine connects-toOsteoblast connects-toCalcium connects-toResistin connects-toNeutrophil connects-toType I Interferon connects-toIl 5 connects-toNatural Killer Cell connects-toPlasma Cell connects-toIge connects-toTslp connects-toPeriostin connects-toC5Ar1 connects-toFactor H connects-toC1 Esterase Inhibitor connects-toTransferrin connects-toBradykinin connects-toErythropoietin connects-toComplement C5 connects-toHistamine connects-toMelatonin connects-toProlactin connects-toTestosterone connects-toSerotonin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toPotassium connects-toZinc connects-toCopper connects-toChloride connects-toSulfur connects-toNitrogen connects-toCarbon connects-toHydrogen connects-toOxygen connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCalcitonin connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toEpinephrine connects-toRenin connects-toMyostatin

Sources