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ankylosing-spondylitis
Ankylosing Spondylitis
Ankylosing spondylitis (AS; radiographic axSpA) is a chronic inflammatory spondyloarthropathy with sacroiliitis and spinal ankylosis; HLA-B27+ in ~90%; IL-17A/IL-23 and TNF pathways drive enthesitis; anti-TNF and anti-IL-17A (secukinumab, ixekizumab) are first-line therapy.
Entry Metadata
| Field | Value |
|---|---|
| ID | ankylosing-spondylitis |
| Name | Ankylosing Spondylitis |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
Sources
- Sieper J, Poddubnyy D. Ankylosing spondylitis. Lancet. 2017;390(10089):73-84. · PubMed 28110981
- Baeten D, Sieper J, Braun J, et al. Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis. N Engl J Med. 2015;373(26):2534-2548. · PubMed 26699169
- van der Heijde D, Ramiro S, Landewé R, et al. 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis. Ann Rheum Dis. 2017;76(6):978-991. · PubMed 28087505