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liver
Liver
Largest internal organ (~1.5 kg), right upper quadrant. Dual blood supply: portal vein (75%) + hepatic artery (25%). Performs >500 functions: glucose/lipid homeostasis, protein synthesis, detoxification, bile secretion. Exceptional regenerative capacity after injury.
Entry Metadata
| Field | Value |
|---|---|
| ID | liver |
| Name | Liver |
| Status | draft |
| Last reviewed | 2026-06-04 |
| Atlas | 01-human |
| Scale | 06-organ |
| Uberon | UBERON:0002107 |
| Fma | FMA:7197 |
Cross-Atlas Connections
containsHepatic Lobule
containsHepatocyte
part-ofDigestive System
connects-toCardiovascular System
damaged-bySars Cov 2
treated-byStatins
infected-byHepatitis B Virus
damaged-byHepatitis B Virus
modulated-byIl 6
modulated-byCortisol
modulated-byInsulin
damaged-byTnf Alpha
damaged-byDengue Virus
treated-byMetformin
containsMacrophage
damaged-byEscherichia Coli
damaged-byStaphylococcus Aureus
damaged-byCandida Albicans
treated-byBerberine
damaged-byHepatitis C Virus
modulated-byCollagen
modulated-byGlucagon
modulated-byThyroid Hormones
modulated-byCopper
modulated-byIron
modulated-bySulfur
modulated-byReproductive System
modulated-byIslet Of Langerhans
modulated-byNeutrophil
modulated-byFibroblast
modulated-byLarge Intestine
modulated-bySmall Intestine
modulated-byStomach
modulated-byThyroid
damaged-byEbola Virus
damaged-byEpstein Barr Virus
damaged-byLeishmania Donovani
damaged-bySalmonella Typhi
damaged-byHelicobacter Pylori
modulated-bySulforaphane
modulated-byResveratrol
modulated-byMilk Thistle
damaged-byRifampicin
Sources
- Hall JE. Guyton and Hall Textbook of Medical Physiology. 14th ed. Elsevier; 2021. Ch. 71.
- Michalopoulos GK. Liver regeneration. J Cell Physiol. 2007;213(2):286-300. · PubMed 17559071
- World Health Organization. Hepatitis B Fact Sheet. WHO; 2023.
- Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology. 2008;134(6):1655-69. · PubMed 18471545
- Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64(1):73-84. · PubMed 26707365