SARS-CoV-2

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sars-cov-2

SARS-CoV-2 (betacoronavirus; sarbecovirus; ~29.9 kb +ssRNA) causes COVID-19 via ACE2/Spike entry; NSP1-16 replicase includes NSP12 RdRp (remdesivir target) and Mpro NSP5 (nirmatrelvir target); multiple IFN evasion proteins; Omicron R₀ >10; mRNA vaccines >90% vs severe disease.

Entry Metadata

Field	Value
ID	sars-cov-2
Name	SARS-CoV-2
Status	draft
Last reviewed	2026-06-08
Atlas	01-human
Scale	07-system

Cross-Atlas Connections

connects-toSars Cov 2 Spike connects-toAce2 connects-toCovid 19 Disease connects-toType I Interferon connects-toMavs connects-toNf Kb connects-toCgas Sting

Sources

Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270-273. · PubMed 32015507
Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020;181(2):271-280. · PubMed 32142651
Lundstrom K. SARS-CoV-2 Omicron Variants and COVID-19 Vaccines — Management and Treatment. Viruses. 2023;15(3):648. · PubMed 36992357
Lei X, Dong X, Ma R, et al. Activation and evasion of type I interferon responses by SARS-CoV-2. Nat Commun. 2020;11(1):3810. · PubMed 32728061