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apoe
APOE
APOE encodes apolipoprotein E, a lipid transport protein with three isoforms; APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease (3-12x risk vs APOE3); APOE4 impairs amyloid-beta clearance and promotes tau pathology via LRP1-mediated mechanisms.
Entry Metadata
| Field | Value |
|---|---|
| ID | apoe |
| Name | APOE |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993;261(5123):921-923. · PubMed 8346443
- Kanekiyo T, Xu H, Bu G. ApoE and Aβ in Alzheimer's disease: accidental encounters or partners? Neuron. 2014;81(4):740-754. · PubMed 24559670