Atlas One · Host Biology · Scale 04 — Cellular

Microglia

CNS-resident macrophages (~5–20% of CNS cells) of haematopoietic (myeloid) origin — unique among glia. Yolk-sac progenitors seed the CNS before BBB formation; maintained by self-renewal (CSF1R/IL-34). Survey ~1000 µm³/min; prune synapses; clear Aβ; drive neuroinflammation.

Also known as: CNS-resident macrophage, brain macrophage, microglial cell, ramified microglia, activated microglia

Scale 04 — CellularScale
draftStatus
2026-06-05Last Reviewed
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microglia

Microglia

CNS-resident macrophages (~5–20% of CNS cells) of haematopoietic (myeloid) origin — unique among glia. Yolk-sac progenitors seed the CNS before BBB formation; maintained by self-renewal (CSF1R/IL-34). Survey ~1000 µm³/min; prune synapses; clear Aβ; drive neuroinflammation.

Entry Metadata

FieldValue
IDmicroglia
NameMicroglia
Statusdraft
Last reviewed2026-06-05
Atlas01-human
Scale04-cellular

Cross-Atlas Connections

part-ofBrain modulatesNeuron modulatesSynapse modulatesNervous System connects-toNeuropathic Pain modulatesBdnf

Sources