This is an auto-generated stub page built from atlas entry frontmatter. A richer
hand-crafted page is planned. See the
atlas source
for the full entry including detailed body sections.
mtor
mTOR
Ser/Thr kinase in two complexes: mTORC1 (rapamycin-sensitive; drives anabolism, suppresses autophagy) and mTORC2 (Akt/SGK1). Integrates nutrient, energy, and growth factor signals; targeted by rapamycin (transplant, TSC) and everolimus (cancer, RCC, PNET).
Entry Metadata
| Field | Value |
|---|---|
| ID | mtor |
| Name | mTOR |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell. 2012;149(2):274-293. · PubMed 22500797
- Heitman J, Movva NR, Hall MN. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science. 1991;253(5022):905-909. · PubMed 1715094
- Saxton RA, Sabatini DM. mTOR Signaling in Growth, Metabolism, and Disease. Cell. 2017;168(6):960-976. · PubMed 28283069