Atlas One · Host Biology · Scale 03 — Molecular

AMPK

Heterotrimeric serine/threonine kinase (α/β/γ) activated by ↑AMP:ATP via LKB1-mediated Thr172 phosphorylation. Master cellular energy sensor: switches off anabolism, switches on catabolism. Metformin activates hepatic AMPK to lower glucose.

Also known as: AMP-activated protein kinase, 5-AMP-activated protein kinase, energy sensor kinase, PRKA

Scale 03 — MolecularScale
draftStatus
2026-06-05Last Reviewed
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ampk

AMPK

Heterotrimeric serine/threonine kinase (α/β/γ) activated by ↑AMP:ATP via LKB1-mediated Thr172 phosphorylation. Master cellular energy sensor: switches off anabolism, switches on catabolism. Metformin activates hepatic AMPK to lower glucose.

Entry Metadata

FieldValue
IDampk
NameAMPK
Statusdraft
Last reviewed2026-06-05
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

modulatesInsulin modulatesHepatocyte modulated-byMetformin modulatesCardiovascular System modulatesMtor modulatesAdipocyte connects-toType 2 Diabetes

Sources