Atlas One · Host Biology · Scale 04 — Cellular

Hepatocyte

Parenchymal cell of the liver comprising ~80% of liver volume. Executes >500 metabolic functions: gluconeogenesis, lipid/cholesterol metabolism, protein synthesis (albumin, clotting factors), urea cycle, phase I/II drug metabolism (CYP450s), and bile acid synthesis.

Also known as: liver parenchymal cell, hepatic cell

Scale 04 — CellularScale
draftStatus
2026-06-04Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
hepatocyte

Hepatocyte

Parenchymal cell of the liver comprising ~80% of liver volume. Executes >500 metabolic functions: gluconeogenesis, lipid/cholesterol metabolism, protein synthesis (albumin, clotting factors), urea cycle, phase I/II drug metabolism (CYP450s), and bile acid synthesis.

Entry Metadata

FieldValue
IDhepatocyte
NameHepatocyte
Statusdraft
Last reviewed2026-06-04
Atlas01-human
Scale04-cellular
Cell OntologyCL:0000182
Lineageendoderm — hepatic endoderm — hepatoblast — hepatocyte

Cross-Atlas Connections

part-ofHepatic Lobule part-ofLiver damaged-bySars Cov 2 modulated-byStatins infected-byHepatitis B Virus damaged-byHepatitis B Virus damaged-byTnf Alpha infected-byPlasmodium Falciparum damaged-byPhoton damaged-byMacrophage target-ofNatural Killer Cell damaged-byEscherichia Coli modulated-byCurcumin modulated-byInsulin Receptor modulated-byStat3 infected-byHepatitis C Virus prevented-byHepatitis C Virus expressed-byFibrinogen modulated-byCholesterol modulated-byEpinephrine modulated-byGlucagon modulated-byAmpk modulated-byAngiotensin Ii expressed-byAlbumin modulated-byLeptin modulated-bySelenium composed-ofPhosphorus composed-ofSulfur modulated-byAdipocyte modulated-bySulforaphane modulated-byMilk Thistle connects-toFamilial Hypercholesterolemia target-ofWarfarin target-ofRifampicin infected-byDengue Virus connects-toHydrogen

Sources