Atlas One · Host Biology · Scale 03 — Molecular

Leptin

16 kDa adipokine encoded by LEP/ob gene. Signals fat mass to hypothalamus via JAK2/STAT3 → suppresses NPY/AgRP, induces POMC → ↓food intake, ↑energy expenditure. Leptin resistance underlies obesity despite high circulating levels.

Also known as: OB protein, adipokine, satiety hormone, obesity hormone, LEP

Scale 03 — MolecularScale
draftStatus
2026-06-05Last Reviewed
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leptin

Leptin

16 kDa adipokine encoded by LEP/ob gene. Signals fat mass to hypothalamus via JAK2/STAT3 → suppresses NPY/AgRP, induces POMC → ↓food intake, ↑energy expenditure. Leptin resistance underlies obesity despite high circulating levels.

Entry Metadata

FieldValue
IDleptin
NameLeptin
Statusdraft
Last reviewed2026-06-05
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

modulatesNervous System modulatesImmune System modulatesT Helper Cell modulatesHepatocyte connects-toObesity connects-toAnorexia Nervosa connects-toBrain connects-toType 2 Diabetes connects-toMajor Depressive Disorder

Sources