Atlas One · Host Biology · Scale 04 — Cellular

T Helper Cell

CD4+ T lymphocyte that orchestrates adaptive immunity. Activated by pMHC-II on dendritic cells, differentiates into Th1/Th2/Th17/Tfh/Treg subsets. Tfh cells drive germinal center reactions and durable antibody production.

Also known as: CD4+ T cell, CD4 T lymphocyte, T helper lymphocyte, Tfh cell, Th1 cell, Th2 cell, Th17 cell

Scale 04 — CellularScale
draftStatus
2026-06-04Last Reviewed
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t-helper-cell

T Helper Cell

CD4+ T lymphocyte that orchestrates adaptive immunity. Activated by pMHC-II on dendritic cells, differentiates into Th1/Th2/Th17/Tfh/Treg subsets. Tfh cells drive germinal center reactions and durable antibody production.

Entry Metadata

FieldValue
IDt-helper-cell
NameT Helper Cell
Statusdraft
Last reviewed2026-06-04
Atlas01-human
Scale04-cellular

Cross-Atlas Connections

part-ofImmune System modulated-byDendritic Cell modulated-byMhc Class Ii modulatesB Cell infected-bySars Cov 2 infected-byHiv 1 damaged-byHiv 1 expressesIl 6 modulated-byNatural Killer Cell part-ofThymus modulated-byLeptin modulated-byZinc modulated-byRegulatory T Cell modulated-byMast Cell infected-byMeasles Virus modulated-byZinc Dietary modulated-byIl 2 modulated-byCalcineurin connects-toIl 31 connects-toIl 17A

Sources