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il-2
IL-2
IL-2 (IL2, chr4q26) is the canonical T cell growth factor; signals via IL-2Rα/β/γc → JAK1/JAK3/STAT5 → proliferation. Low-dose expands Tregs (clinical trials in SLE, GVHD); high-dose aldesleukin approved for metastatic RCC and melanoma (FDA 1992/1998).
Entry Metadata
| Field | Value |
|---|---|
| ID | il-2 |
| Name | IL-2 |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Morgan DA, Ruscetti FW, Gallo R. Selective in vitro growth of T lymphocytes from normal human bone marrows. Science. 1976;193(4257):1007-1008. · PubMed 181845
- Rosenberg SA, Lotze MT, Muul LM, et al. Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. N Engl J Med. 1985;313(23):1485-1492. · PubMed 3903516
- Klatzmann D, Abbas AK. The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases. Nat Rev Immunol. 2015;15(5):283-294. · PubMed 25882245
- Abbas AK, Lichtman AH, Pillai S. Cellular and Molecular Immunology. 9th ed. Elsevier; 2018.