This is an auto-generated stub page built from atlas entry frontmatter. A richer
hand-crafted page is planned. See the
atlas source
for the full entry including detailed body sections.
immune-thrombocytopenia
Immune Thrombocytopenia
Immune thrombocytopenia (ITP): anti-platelet IgG (anti-GPIIb/IIIa) → FcγR-mediated splenic destruction + CD8+ T-cell lysis; platelet <100×10⁹/L. Corticosteroids/IVIG first-line; romiplostim, eltrombopag (TPO-RAs); efgartigimod (FcRn inhibitor; FDA Jun 2023).
Entry Metadata
| Field | Value |
|---|---|
| ID | immune-thrombocytopenia |
| Name | Immune Thrombocytopenia |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
Sources
- Cines DB, Blanchette VS. Immune thrombocytopenic purpura. N Engl J Med. 2002;346(13):995-1008. · PubMed 11919310
- Neunert C, Terrell DR, Arnold DM, et al. American Society of Hematology 2019 guidelines for immune thrombocytopenia. Blood Adv. 2019;3(23):3829-3866. · PubMed 31794604
- Bussel JB, Kuter DJ, George JN, et al. AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP. N Engl J Med. 2006;355(16):1672-1681. · PubMed 17050891
- Cheng G, Saleh MN, Marcher C, et al. Eltrombopag for management of chronic immune thrombocytopenia (RAISE). Lancet. 2011;377(9763):393-402. · PubMed 21237459