Atlas One · Host Biology · Scale 07 — System

Waldenström Macroglobulinemia

Waldenström macroglobulinemia is lymphoplasmacytic lymphoma producing IgM monoclonal protein; MYD88 L265P in ~90% drives NF-κB and JAK-STAT3. Hyperviscosity, neuropathy, and cryoglobulinemia are hallmarks; ibrutinib and zanubrutinib are approved for MYD88 L265P WM.

Also known as: Waldenström macroglobulinemia, WM, lymphoplasmacytic lymphoma, LPL, IgM monoclonal protein, IgM paraprotein, hyperviscosity syndrome, MYD88 L265P WM

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
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waldenstrom-macroglobulinemia

Waldenström Macroglobulinemia

Waldenström macroglobulinemia is lymphoplasmacytic lymphoma producing IgM monoclonal protein; MYD88 L265P in ~90% drives NF-κB and JAK-STAT3. Hyperviscosity, neuropathy, and cryoglobulinemia are hallmarks; ibrutinib and zanubrutinib are approved for MYD88 L265P WM.

Entry Metadata

FieldValue
IDwaldenstrom-macroglobulinemia
NameWaldenström Macroglobulinemia
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toNf Kb connects-toJak1 2 connects-toBcl 2 connects-toCd20 connects-toCxcl12 connects-toB Cell connects-toMyd88 connects-toPeripheral Nerve connects-toMultiple Myeloma connects-toPlasma Cell connects-toBone Marrow connects-toFollicular Lymphoma connects-toDlbcl connects-toStroke connects-toMantle Cell Lymphoma connects-toCll connects-toHepatitis C connects-toBtk connects-toErythrocyte connects-toEye connects-toPlatelet connects-toSpleen connects-toAnemia Of Chronic Disease connects-toPcnsl connects-toComplement C3 connects-toMast Cell connects-toAlbumin connects-toAutophagy connects-toRegulatory T Cell connects-toBrain connects-toIron connects-toEndothelial Cell connects-toPhoton connects-toLiver connects-toSodium connects-toElectron connects-toKidney connects-toSkin connects-toAntibody connects-toNeuron connects-toHeart connects-toLymphatic System connects-toLarge Intestine connects-toNeutrophil connects-toNeuropathic Pain connects-toIl 6 connects-toNatural Killer Cell connects-toIl 10 connects-toImmune Thrombocytopenia connects-toMacrophage connects-toStat3 connects-toNervous System connects-toSepsis connects-toVenous Thromboembolism connects-toCkd connects-toPneumocystis Jirovecii connects-toAspergillus Fumigatus connects-toHeart Failure connects-toMajor Depressive Disorder connects-toVaricella Zoster Virus connects-toIntegumentary System connects-toGeneralized Anxiety Disorder connects-toImmune System connects-toDigestive System connects-toMusculoskeletal System connects-toCardiovascular System connects-toRespiratory System connects-toRenal System connects-toTargeted Therapy connects-toHepatitis C Virus connects-toCancer Chemotherapy connects-toGerminal Center connects-toGlomerulus connects-toSjogrens Syndrome connects-toArterial Wall connects-toMyocardium connects-toHemophilia A connects-toCidp connects-toHereditary Angioedema connects-toHepatic Lobule connects-toVon Willebrand Factor connects-toCardiac Conduction System connects-toCovid 19 Disease connects-toVegf connects-toTnf Alpha connects-toHif 1Alpha connects-toBaff connects-toMtor connects-toComplement C5 connects-toTlr4 connects-toPik3Ca connects-toKit connects-toCaspase 3 connects-toErythropoietin connects-toCcl2 connects-toAkt connects-toErk1 2 connects-toMyc connects-toSrc Kinase connects-toP53 connects-toE2F1 connects-toPten connects-toCdkn2A connects-toTert connects-toGalectin 3 connects-toEzh2 connects-toStat1 connects-toFoxo connects-toCdk4 6 connects-toSmad4 connects-toGsk 3B connects-toMdm2 connects-toPerforin connects-toDnmt3A connects-toAmpk connects-toS100A8 A9 connects-toCcr5 connects-toArid1A connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toCalcineurin connects-toHemoglobin connects-toHepcidin connects-toMhc Class Ii connects-toImmunoglobulin G connects-toThrombin connects-toIl 2 connects-toIl 4 connects-toNitric Oxide connects-toXanthine Oxidase connects-toAdiponectin connects-toLeptin connects-toResistin connects-toIl 13 connects-toPd 1 connects-toCtla 4 connects-toType I Interferon connects-toMacrophage connects-toLiver connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toT Cytotoxic Cell connects-toT Helper Cell connects-toC5Ar1 connects-toDendritic Cell connects-toFactor H connects-toC1 Esterase Inhibitor connects-toTransferrin connects-toTslp connects-toBradykinin connects-toHistamine connects-toPeriostin connects-toMelatonin connects-toProlactin connects-toTestosterone connects-toSerotonin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toZinc connects-toMagnesium connects-toCopper connects-toPotassium connects-toCalcium connects-toCarbon connects-toChloride connects-toHydrogen connects-toNitrogen connects-toSulfur connects-toOxygen connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf

Sources