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iodine
Iodine
Iodine (I⁻, atomic number 53) — 15–20 mg total, ~75% in thyroid. Essential for T3/T4 synthesis via NIS uptake, TPO organification, and thyroglobulin coupling. Deficiency causes goitre, hypothyroidism, and cretinism — the leading preventable cause of intellectual disability.
Entry Metadata
| Field | Value |
|---|---|
| ID | iodine |
| Name | Iodine |
| Status | draft |
| Last reviewed | 2026-06-05 |
| Atlas | 01-human |
| Scale | 02-atomic |
Cross-Atlas Connections
Sources
- Berg JM, Tymoczko JL, Stryer L. Biochemistry. 9th ed. W.H. Freeman; 2019.
- Hall JE, Hall ME. Guyton and Hall Textbook of Medical Physiology. 14th ed. Elsevier; 2021.
- Bizhanova A, Kopp P. Minireview: The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid. Endocrinology. 2009;150(3):1084-90. · PubMed 19196800
- Zimmermann MB, Boelaert K. Iodine deficiency and thyroid disorders. Lancet Diabetes Endocrinol. 2015;3(4):286-95. · PubMed 25591468