Atlas One · Host Biology · Scale 03 — Molecular

S100A8/A9

S100A8/A9 (calprotectin) is a neutrophil alarmin activating TLR4/RAGE → NF-κB and recruiting myeloid cells; fecal calprotectin is the gold-standard non-invasive biomarker of mucosal inflammation in IBD; serum S100A8/A9 (MRP8/14) is elevated in RA, sepsis, and COVID-19.

Also known as: S100A8, S100A9, calprotectin, MRP8, MRP14, MRP8/14, S100A8/A9, fecal calprotectin, alarmin, DAMP

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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s100a8-a9

S100A8/A9

S100A8/A9 (calprotectin) is a neutrophil alarmin activating TLR4/RAGE → NF-κB and recruiting myeloid cells; fecal calprotectin is the gold-standard non-invasive biomarker of mucosal inflammation in IBD; serum S100A8/A9 (MRP8/14) is elevated in RA, sepsis, and COVID-19.

Entry Metadata

FieldValue
IDs100a8-a9
NameS100A8/A9
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toInflammatory Bowel Disease connects-toNlrp3 Inflammasome connects-toRage connects-toRheumatoid Arthritis

Sources