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rheumatoid-arthritis
Rheumatoid Arthritis
Autoimmune synovitis from Th17/macrophage TNF-alpha and IL-6 activation; ACPA/anti-CCP antibodies are diagnostic. Methotrexate is first-line; TNF inhibitors (adalimumab), IL-6 blockade (tocilizumab), and JAK inhibitors (baricitinib) for refractory disease.
Entry Metadata
| Field | Value |
|---|---|
| ID | rheumatoid-arthritis |
| Name | Rheumatoid Arthritis |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toTnf Alpha
connects-toIl 6
connects-toT Helper Cell
connects-toNf Kb
connects-toIl 17A
connects-toCcr5
connects-toCcl2
treated-byIbuprofen
treated-byCorticosteroids
treated-byAdalimumab
connects-toPsoriatic Arthritis
connects-toSjogrens Syndrome
connects-toFibroblast
connects-toSystemic Lupus Erythematosus
connects-toOsteoporosis
connects-toB Cell
connects-toOsteoclast
connects-toLung
connects-toCardiovascular System
connects-toJak1 2
connects-toMacrophage
connects-toMusculoskeletal System
connects-toMhc Class Ii
connects-toGut Microbiome
connects-toRegulatory T Cell
connects-toRankl
connects-toCollagen
connects-toDendritic Cell
connects-toIron
connects-toHeart
connects-toNeutrophil
connects-toEye
connects-toFibrosis
connects-toCalcium
connects-toPhoton
connects-toSpleen
connects-toComplement C3
connects-toLiver
connects-toPlasma Cell
connects-toErythrocyte
connects-toAntibody
connects-toPeripheral Nerve
connects-toKidney
connects-toAtherosclerosis
connects-toMast Cell
connects-toIl 1B
connects-toCtla 4
connects-toEndothelial Cell
connects-toAnemia Of Chronic Disease
connects-toEpstein Barr Virus
connects-toDlbcl
connects-toNlrp3 Inflammasome
connects-toTuberculosis
connects-toPneumocystis Jirovecii
connects-toHepatitis B Virus
connects-toAspergillus Fumigatus
connects-toMajor Depressive Disorder
connects-toVenous Thromboembolism
connects-toVaricella Zoster Virus
connects-toCkd
connects-toGeneralized Anxiety Disorder
connects-toRespiratory System
connects-toNervous System
connects-toImmune System
connects-toIntegumentary System
connects-toLymphatic System
connects-toRenal System
connects-toDigestive System
connects-toReproductive System
connects-toEndocrine System
connects-toCancer Chemotherapy
connects-toAnkylosing Spondylitis
connects-toCortical Bone
connects-toGerminal Center
connects-toMultiple Sclerosis
connects-toImmune Thrombocytopenia
connects-toArterial Wall
connects-toAlveolus
connects-toIga Nephropathy
connects-toPtcl
connects-toGout
connects-toPsoriasis
connects-toVegf
connects-toBaff
connects-toIl 23
connects-toIfn Gamma
connects-toHif 1Alpha
connects-toPdgf
connects-toCd20
connects-toS100A8 A9
connects-toFibronectin
connects-toProstaglandins
connects-toIl 33
connects-toTgf Beta
connects-toFibrinogen
connects-toBtk
connects-toComplement C5
connects-toStat3
connects-toMyd88
connects-toIl 10
connects-toTlr4
connects-toMtor
connects-toAkt
connects-toErk1 2
connects-toGalectin 3
connects-toStat1
connects-toCgas Sting
connects-toSmad4
connects-toPerforin
connects-toFoxo
connects-toGsk 3B
connects-toSrc Kinase
connects-toPik3Ca
connects-toAmpk
connects-toAutophagy
connects-toDnmt3A
connects-toCalcineurin
connects-toCxcl12
connects-toAdenosine
connects-toType I Interferon
connects-toOsteopontin
connects-toImmunoglobulin G
connects-toNitric Oxide
connects-toAngiopoietin
connects-toHemoglobin
connects-toTroponin Complex
connects-toEstrogen
connects-toCholesterol
connects-toXanthine Oxidase
connects-toAdiponectin
connects-toHepcidin
connects-toLeptin
connects-toInsulin
connects-toResistin
connects-toIl 4
connects-toIl 13
connects-toZinc
connects-toSelenium
connects-toHistamine
connects-toIl 12
connects-toIl 5
connects-toNatural Killer Cell
connects-toT Cytotoxic Cell
connects-toIge
connects-toVitamin D
connects-toC5Ar1
connects-toTslp
connects-toPeriostin
connects-toFactor H
connects-toC1 Esterase Inhibitor
connects-toTransferrin
connects-toBradykinin
connects-toErythropoietin
connects-toProlactin
connects-toMelatonin
connects-toOxytocin
connects-toTestosterone
connects-toSerotonin
connects-toVasopressin
connects-toMagnesium
connects-toIodine
connects-toSodium
connects-toCopper
connects-toPotassium
connects-toPhosphorus
connects-toChloride
connects-toSulfur
connects-toNitrogen
connects-toOxygen
connects-toCarbon
connects-toHydrogen
connects-toPd 1
connects-toGlp 1
connects-toAngiotensin Ii
connects-toWnt Beta Catenin
connects-toIl 2
connects-toNotch
connects-toIgf 1
connects-toActivin A
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAldosterone
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toBdnf
connects-toFgfr
connects-toEpinephrine
connects-toRenin
connects-toMyostatin
connects-toCortisol
Sources
- Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis. Lancet. 2016;388(10055):2023-2038. · PubMed 27156434
- Firestein GS. Evolving concepts of rheumatoid arthritis. Nature. 2003;423(6937):356-361. · PubMed 12748655
- Genovese MC, Kremer J, Zamani O, et al. Baricitinib in Patients with Refractory Rheumatoid Arthritis. N Engl J Med. 2016;374(13):1243-1252. · PubMed 27028914