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rheumatoid-arthritis
Rheumatoid Arthritis
Autoimmune synovitis from Th17/macrophage TNF-alpha and IL-6 activation; ACPA/anti-CCP antibodies are diagnostic. Methotrexate is first-line; TNF inhibitors (adalimumab), IL-6 blockade (tocilizumab), and JAK inhibitors (baricitinib) for refractory disease.
Entry Metadata
| Field | Value |
|---|---|
| ID | rheumatoid-arthritis |
| Name | Rheumatoid Arthritis |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
Sources
- Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis. Lancet. 2016;388(10055):2023-2038. · PubMed 27156434
- Firestein GS. Evolving concepts of rheumatoid arthritis. Nature. 2003;423(6937):356-361. · PubMed 12748655
- Genovese MC, Kremer J, Zamani O, et al. Baricitinib in Patients with Refractory Rheumatoid Arthritis. N Engl J Med. 2016;374(13):1243-1252. · PubMed 27028914