Atlas One · Host Biology · Scale 07 — System

Rheumatoid Arthritis

Autoimmune synovitis from Th17/macrophage TNF-alpha and IL-6 activation; ACPA/anti-CCP antibodies are diagnostic. Methotrexate is first-line; TNF inhibitors (adalimumab), IL-6 blockade (tocilizumab), and JAK inhibitors (baricitinib) for refractory disease.

Also known as: RA, rheumatoid disease, adult RA, seropositive arthritis, inflammatory arthritis

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
rheumatoid-arthritis

Rheumatoid Arthritis

Autoimmune synovitis from Th17/macrophage TNF-alpha and IL-6 activation; ACPA/anti-CCP antibodies are diagnostic. Methotrexate is first-line; TNF inhibitors (adalimumab), IL-6 blockade (tocilizumab), and JAK inhibitors (baricitinib) for refractory disease.

Entry Metadata

FieldValue
IDrheumatoid-arthritis
NameRheumatoid Arthritis
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toTnf Alpha connects-toIl 6 connects-toT Helper Cell connects-toNf Kb connects-toIl 17A connects-toCcr5 connects-toCcl2 treated-byIbuprofen treated-byCorticosteroids treated-byAdalimumab connects-toPsoriatic Arthritis connects-toSjogrens Syndrome connects-toFibroblast connects-toSystemic Lupus Erythematosus connects-toOsteoporosis connects-toB Cell connects-toOsteoclast connects-toLung connects-toCardiovascular System connects-toJak1 2 connects-toMacrophage connects-toMusculoskeletal System connects-toMhc Class Ii connects-toGut Microbiome connects-toRegulatory T Cell connects-toRankl connects-toCollagen connects-toDendritic Cell connects-toIron connects-toHeart connects-toNeutrophil connects-toEye connects-toFibrosis connects-toCalcium connects-toPhoton connects-toSpleen connects-toComplement C3 connects-toLiver connects-toPlasma Cell connects-toErythrocyte connects-toAntibody connects-toPeripheral Nerve connects-toKidney connects-toAtherosclerosis connects-toMast Cell connects-toIl 1B connects-toCtla 4 connects-toEndothelial Cell connects-toAnemia Of Chronic Disease connects-toEpstein Barr Virus connects-toDlbcl connects-toNlrp3 Inflammasome connects-toTuberculosis connects-toPneumocystis Jirovecii connects-toHepatitis B Virus connects-toAspergillus Fumigatus connects-toMajor Depressive Disorder connects-toVenous Thromboembolism connects-toVaricella Zoster Virus connects-toCkd connects-toGeneralized Anxiety Disorder connects-toRespiratory System connects-toNervous System connects-toImmune System connects-toIntegumentary System connects-toLymphatic System connects-toRenal System connects-toDigestive System connects-toReproductive System connects-toEndocrine System connects-toCancer Chemotherapy connects-toAnkylosing Spondylitis connects-toCortical Bone connects-toGerminal Center connects-toMultiple Sclerosis connects-toImmune Thrombocytopenia connects-toArterial Wall connects-toAlveolus connects-toIga Nephropathy connects-toPtcl connects-toGout connects-toPsoriasis connects-toVegf connects-toBaff connects-toIl 23 connects-toIfn Gamma connects-toHif 1Alpha connects-toPdgf connects-toCd20 connects-toS100A8 A9 connects-toFibronectin connects-toProstaglandins connects-toIl 33 connects-toTgf Beta connects-toFibrinogen connects-toBtk connects-toComplement C5 connects-toStat3 connects-toMyd88 connects-toIl 10 connects-toTlr4 connects-toMtor connects-toAkt connects-toErk1 2 connects-toGalectin 3 connects-toStat1 connects-toCgas Sting connects-toSmad4 connects-toPerforin connects-toFoxo connects-toGsk 3B connects-toSrc Kinase connects-toPik3Ca connects-toAmpk connects-toAutophagy connects-toDnmt3A connects-toCalcineurin connects-toCxcl12 connects-toAdenosine connects-toType I Interferon connects-toOsteopontin connects-toImmunoglobulin G connects-toNitric Oxide connects-toAngiopoietin connects-toHemoglobin connects-toTroponin Complex connects-toEstrogen connects-toCholesterol connects-toXanthine Oxidase connects-toAdiponectin connects-toHepcidin connects-toLeptin connects-toInsulin connects-toResistin connects-toIl 4 connects-toIl 13 connects-toZinc connects-toSelenium connects-toHistamine connects-toIl 12 connects-toIl 5 connects-toNatural Killer Cell connects-toT Cytotoxic Cell connects-toIge connects-toVitamin D connects-toC5Ar1 connects-toTslp connects-toPeriostin connects-toFactor H connects-toC1 Esterase Inhibitor connects-toTransferrin connects-toBradykinin connects-toErythropoietin connects-toProlactin connects-toMelatonin connects-toOxytocin connects-toTestosterone connects-toSerotonin connects-toVasopressin connects-toMagnesium connects-toIodine connects-toSodium connects-toCopper connects-toPotassium connects-toPhosphorus connects-toChloride connects-toSulfur connects-toNitrogen connects-toOxygen connects-toCarbon connects-toHydrogen connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toIl 2 connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr connects-toEpinephrine connects-toRenin connects-toMyostatin connects-toCortisol