Atlas One · Host Biology · Scale 07 — System

Anemia of Chronic Disease

Anemia of chronic disease (ACD) is anemia from chronic inflammation (infection, autoimmune disease, malignancy, CKD); IL-6 → hepcidin → ferroportin degradation → iron sequestration → iron-restricted erythropoiesis. Treat underlying cause; IV iron and ESAs in CKD.

Also known as: ACD, anemia of chronic disease, anemia of inflammation, AI, functional iron deficiency, AOCD, inflammatory anemia, iron sequestration anemia

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
anemia-of-chronic-disease

Anemia of Chronic Disease

Anemia of chronic disease (ACD) is anemia from chronic inflammation (infection, autoimmune disease, malignancy, CKD); IL-6 → hepcidin → ferroportin degradation → iron sequestration → iron-restricted erythropoiesis. Treat underlying cause; IV iron and ESAs in CKD.

Entry Metadata

FieldValue
IDanemia-of-chronic-disease
NameAnemia of Chronic Disease
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toHepcidin connects-toIl 6 connects-toErythropoietin connects-toCkd connects-toFerroportin connects-toIl 12 connects-toTuberculosis connects-toHiv Aids connects-toLeishmaniasis connects-toIron Deficiency Anemia connects-toMacrophage connects-toRheumatoid Arthritis connects-toErythrocyte connects-toInflammatory Bowel Disease connects-toSystemic Lupus Erythematosus connects-toIron connects-toMds connects-toMultiple Myeloma connects-toBone Marrow connects-toTransferrin connects-toImmune System connects-toLiver connects-toHeart Failure connects-toTnf Alpha connects-toHepatocyte connects-toHif 1Alpha connects-toSpleen connects-toOxygen connects-toKidney connects-toHemoglobin connects-toSmall Intestine connects-toHeart connects-toIfn Gamma connects-toPhoton connects-toCopper connects-toStat3 connects-toElectron connects-toVitamin D connects-toLarge Intestine connects-toPlatelet connects-toAlbumin connects-toT Helper Cell connects-toAntibody connects-toObesity connects-toSkin connects-toMalaria connects-toNeutrophil connects-toColorectal Cancer connects-toNf Kb connects-toSepsis connects-toT Cytotoxic Cell connects-toCopd connects-toCml connects-toSickle Cell Disease connects-toAnkylosing Spondylitis connects-toHepatitis C connects-toProstate Cancer connects-toPsoriatic Arthritis connects-toDlbcl connects-toMajor Depressive Disorder connects-toDigestive System connects-toEndocrine System connects-toHelicobacter Pylori connects-toIntegumentary System connects-toNervous System connects-toReproductive System connects-toCardiovascular System connects-toLymphatic System connects-toRespiratory System connects-toRenal System connects-toMusculoskeletal System connects-toMycobacterium Tuberculosis connects-toHepatic Lobule connects-toCancer Chemotherapy connects-toAplastic Anemia connects-toMyocardium connects-toCovid 19 Disease connects-toMyelofibrosis connects-toGiant Cell Arteritis connects-toSystemic Sclerosis connects-toHepatitis B connects-toIntestinal Epithelium connects-toOvarian Cancer connects-toType 2 Diabetes connects-toIl 1B connects-toNlrp3 Inflammasome connects-toAnca Vasculitis connects-toActivin A connects-toTlr4 connects-toS100A8 A9 connects-toTgf Beta connects-toCaspase 3 connects-toType I Interferon connects-toEgln1 connects-toXanthine Oxidase connects-toRage connects-toSmad4 connects-toJak1 2 connects-toAkt connects-toMyd88 connects-toStat1 connects-toBcl 2 connects-toErk1 2 connects-toMtor connects-toPten connects-toGalectin 3 connects-toCgas Sting connects-toCcl2 connects-toFoxo connects-toPik3Ca connects-toCdk4 6 connects-toGsk 3B connects-toPerforin connects-toAutophagy connects-toAmpk connects-toSrc Kinase connects-toCcr5 connects-toDnmt3A connects-toCxcl12 connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toArid1A connects-toTestosterone connects-toIgf 1 connects-toNfe2L2 connects-toEstrogen connects-toIl 10 connects-toZinc connects-toProstaglandins connects-toIl 4 connects-toNitric Oxide connects-toIl 13 connects-toZinc connects-toInflammatory Bowel Disease connects-toHodgkin Lymphoma connects-toLeptin connects-toAdiponectin connects-toResistin connects-toInflammatory Bowel Disease connects-toLiver connects-toNatural Killer Cell connects-toIl 5 connects-toIl 23 connects-toIge connects-toPlasma Cell connects-toDendritic Cell connects-toMast Cell connects-toComplement C5 connects-toC5Ar1 connects-toFactor H connects-toC1 Esterase Inhibitor connects-toOsteopontin connects-toTslp connects-toBradykinin connects-toHistamine connects-toPeriostin connects-toMelatonin connects-toProlactin connects-toSerotonin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toPotassium connects-toCalcium connects-toPhosphorus connects-toChloride connects-toSulfur connects-toNitrogen connects-toCarbon connects-toHydrogen connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toIl 2 connects-toVegf connects-toFibronectin connects-toNotch connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr

Sources