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anemia-of-chronic-disease
Anemia of Chronic Disease
Anemia of chronic disease (ACD) is anemia from chronic inflammation (infection, autoimmune disease, malignancy, CKD); IL-6 → hepcidin → ferroportin degradation → iron sequestration → iron-restricted erythropoiesis. Treat underlying cause; IV iron and ESAs in CKD.
Entry Metadata
| Field | Value |
|---|---|
| ID | anemia-of-chronic-disease |
| Name | Anemia of Chronic Disease |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
Sources
- Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005;352(10):1011-1023. · PubMed 15758012
- Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004;113(9):1271-1276. · PubMed 15124018
- Ganz T. Anemia of Inflammation. N Engl J Med. 2019;381(12):1148-1157. · PubMed 31532961