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covid-19-disease
COVID-19 Disease
Multisystem infectious disease caused by SARS-CoV-2; clinical spectrum from asymptomatic to severe ARDS and cytokine storm. Spike protein binds ACE2 for cell entry; hyperinflammation drives severe disease; mRNA vaccines (mRNA-1273, BNT162b2) provide high efficacy.
Entry Metadata
| Field | Value |
|---|---|
| ID | covid-19-disease |
| Name | COVID-19 Disease |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
modulatesAce2
connects-toCytokine Storm
targetsLung
targetsRespiratory System
connects-toSars Cov 2
connects-toSars Cov 2 Spike
connects-toRsv
connects-toInfluenza
connects-toType Ii Pneumocyte
treated-byDexamethasone
treated-byCorticosteroids
connects-toVenous Thromboembolism
connects-toEndothelial Cell
connects-toMacrophage
connects-toArds
connects-toType 2 Diabetes
connects-toStroke
targetsAlveolus
connects-toType I Interferon
connects-toNeutrophil
connects-toBrain
connects-toHeart
connects-toB Cell
connects-toT Cytotoxic Cell
connects-toIl 6
connects-toKidney
connects-toAngiotensin Ii
connects-toFibrinogen
connects-toNatural Killer Cell
connects-toOxygen
connects-toLarge Intestine
connects-toPlatelet
connects-toPhoton
connects-toFibrosis
connects-toIron
connects-toElectron
connects-toSkin
connects-toVitamin D
connects-toNeuron
connects-toLiver
connects-toPancreas
connects-toAntibody
connects-toReproductive System
connects-toT Helper Cell
connects-toCardiomyocyte
connects-toNlrp3 Inflammasome
connects-toThyroid
connects-toBradykinin
connects-toGuillain Barre
connects-toMast Cell
connects-toNf Kb
connects-toStat3
connects-toSepsis
connects-toAspergillus Fumigatus
connects-toCkd
connects-toMajor Depressive Disorder
connects-toHeart Failure
connects-toPulmonary Arterial Hypertension
connects-toPtsd
connects-toImmune System
connects-toNervous System
connects-toGeneralized Anxiety Disorder
connects-toCardiovascular System
connects-toDigestive System
connects-toIntegumentary System
connects-toLymphatic System
connects-toRenal System
connects-toEndocrine System
connects-toMusculoskeletal System
connects-toTargeted Therapy
connects-toStreptococcus Pneumoniae
connects-toWarfarin
connects-toMyocardium
connects-toArterial Wall
connects-toGlomerulus
connects-toFibromyalgia
connects-toType 1 Diabetes
connects-toGerminal Center
connects-toObesity
connects-toBone Marrow
connects-toAtherosclerosis
connects-toDisseminated Intravascular Coagulation
connects-toTuberculosis
connects-toComplement C5
connects-toIl 1B
connects-toTnf Alpha
connects-toIfn Gamma
connects-toCcl2
connects-toHif 1Alpha
connects-toJak1 2
connects-toVon Willebrand Factor
connects-toTlr4
connects-toGlucocorticoid Receptor
connects-toRig I
connects-toThrombin
connects-toMavs
connects-toIrf3
connects-toPf4
connects-toStat1
connects-toMyd88
connects-toAngiopoietin
connects-toComplement C3
connects-toCgas Sting
connects-toPerforin
connects-toGalectin 3
connects-toSmad4
connects-toAkt
connects-toS100A8 A9
connects-toFoxo
connects-toErk1 2
connects-toMtor
connects-toGsk 3B
connects-toPik3Ca
connects-toAmpk
connects-toAutophagy
connects-toSrc Kinase
connects-toCcr5
connects-toDnmt3A
connects-toCxcl12
connects-toIl 33
connects-toIl 17A
connects-toArid1A
connects-toImmunoglobulin G
connects-toTroponin Complex
connects-toSurfactant
connects-toSecretory Iga
connects-toMhc Class Ii
connects-toIl 2
connects-toNitric Oxide
connects-toVegf
connects-toIl 10
connects-toProstaglandins
connects-toRenin
connects-toZinc
connects-toHepcidin
connects-toSelenium
connects-toLeptin
connects-toAdiponectin
connects-toResistin
connects-toIl 4
connects-toSars Cov 2
connects-toIl 12
connects-toIl 13
connects-toIl 5
connects-toIl 23
connects-toIge
connects-toSars Cov 2
connects-toDendritic Cell
connects-toC5Ar1
connects-toFactor H
connects-toC1 Esterase Inhibitor
connects-toTransferrin
connects-toTslp
connects-toErythropoietin
connects-toHistamine
connects-toPeriostin
connects-toMelatonin
connects-toProlactin
connects-toTestosterone
connects-toSerotonin
connects-toOxytocin
connects-toVasopressin
connects-toIodine
connects-toSodium
connects-toMagnesium
connects-toCopper
connects-toPotassium
connects-toCalcium
connects-toPhosphorus
connects-toChloride
connects-toSulfur
connects-toNitrogen
connects-toCarbon
connects-toHydrogen
connects-toPd 1
connects-toGlp 1
connects-toWnt Beta Catenin
connects-toRankl
connects-toFibronectin
connects-toNotch
connects-toIgf 1
connects-toActivin A
connects-toTgf Beta
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAldosterone
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toBdnf
connects-toOsteopontin
Sources
- Guan WJ, Ni ZY, Hu Y, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;382(18):1708-1720. · PubMed 32109013
- Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020;181(2):271-280. · PubMed 32142651
- Polack FP, Thomas SJ, Kitchin N, et al. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. N Engl J Med. 2020;383(27):2603-2615. · PubMed 33301246