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covid-19-disease
COVID-19 Disease
Multisystem infectious disease caused by SARS-CoV-2; clinical spectrum from asymptomatic to severe ARDS and cytokine storm. Spike protein binds ACE2 for cell entry; hyperinflammation drives severe disease; mRNA vaccines (mRNA-1273, BNT162b2) provide high efficacy.
Entry Metadata
| Field | Value |
|---|---|
| ID | covid-19-disease |
| Name | COVID-19 Disease |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
Sources
- Guan WJ, Ni ZY, Hu Y, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;382(18):1708-1720. · PubMed 32109013
- Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020;181(2):271-280. · PubMed 32142651
- Polack FP, Thomas SJ, Kitchin N, et al. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. N Engl J Med. 2020;383(27):2603-2615. · PubMed 33301246