Atlas One · Host Biology · Scale 07 — System

COVID-19 Disease

Multisystem infectious disease caused by SARS-CoV-2; clinical spectrum from asymptomatic to severe ARDS and cytokine storm. Spike protein binds ACE2 for cell entry; hyperinflammation drives severe disease; mRNA vaccines (mRNA-1273, BNT162b2) provide high efficacy.

Also known as: COVID-19, coronavirus disease 2019, SARS-CoV-2 infection, COVID

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
covid-19-disease

COVID-19 Disease

Multisystem infectious disease caused by SARS-CoV-2; clinical spectrum from asymptomatic to severe ARDS and cytokine storm. Spike protein binds ACE2 for cell entry; hyperinflammation drives severe disease; mRNA vaccines (mRNA-1273, BNT162b2) provide high efficacy.

Entry Metadata

FieldValue
IDcovid-19-disease
NameCOVID-19 Disease
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

modulatesAce2 connects-toCytokine Storm targetsLung targetsRespiratory System connects-toSars Cov 2 connects-toSars Cov 2 Spike connects-toRsv connects-toInfluenza connects-toType Ii Pneumocyte treated-byDexamethasone treated-byCorticosteroids connects-toVenous Thromboembolism connects-toEndothelial Cell connects-toMacrophage connects-toArds connects-toType 2 Diabetes connects-toStroke targetsAlveolus connects-toType I Interferon connects-toNeutrophil connects-toBrain connects-toHeart connects-toB Cell connects-toT Cytotoxic Cell connects-toIl 6 connects-toKidney connects-toAngiotensin Ii connects-toFibrinogen connects-toNatural Killer Cell connects-toOxygen connects-toLarge Intestine connects-toPlatelet connects-toPhoton connects-toFibrosis connects-toIron connects-toElectron connects-toSkin connects-toVitamin D connects-toNeuron connects-toLiver connects-toPancreas connects-toAntibody connects-toReproductive System connects-toT Helper Cell connects-toCardiomyocyte connects-toNlrp3 Inflammasome connects-toThyroid connects-toBradykinin connects-toGuillain Barre connects-toMast Cell connects-toNf Kb connects-toStat3 connects-toSepsis connects-toAspergillus Fumigatus connects-toCkd connects-toMajor Depressive Disorder connects-toHeart Failure connects-toPulmonary Arterial Hypertension connects-toPtsd connects-toImmune System connects-toNervous System connects-toGeneralized Anxiety Disorder connects-toCardiovascular System connects-toDigestive System connects-toIntegumentary System connects-toLymphatic System connects-toRenal System connects-toEndocrine System connects-toMusculoskeletal System connects-toTargeted Therapy connects-toStreptococcus Pneumoniae connects-toWarfarin connects-toMyocardium connects-toArterial Wall connects-toGlomerulus connects-toFibromyalgia connects-toType 1 Diabetes connects-toGerminal Center connects-toObesity connects-toBone Marrow connects-toAtherosclerosis connects-toDisseminated Intravascular Coagulation connects-toTuberculosis connects-toComplement C5 connects-toIl 1B connects-toTnf Alpha connects-toIfn Gamma connects-toCcl2 connects-toHif 1Alpha connects-toJak1 2 connects-toVon Willebrand Factor connects-toTlr4 connects-toGlucocorticoid Receptor connects-toRig I connects-toThrombin connects-toMavs connects-toIrf3 connects-toPf4 connects-toStat1 connects-toMyd88 connects-toAngiopoietin connects-toComplement C3 connects-toCgas Sting connects-toPerforin connects-toGalectin 3 connects-toSmad4 connects-toAkt connects-toS100A8 A9 connects-toFoxo connects-toErk1 2 connects-toMtor connects-toGsk 3B connects-toPik3Ca connects-toAmpk connects-toAutophagy connects-toSrc Kinase connects-toCcr5 connects-toDnmt3A connects-toCxcl12 connects-toIl 33 connects-toIl 17A connects-toArid1A connects-toImmunoglobulin G connects-toTroponin Complex connects-toSurfactant connects-toSecretory Iga connects-toMhc Class Ii connects-toIl 2 connects-toNitric Oxide connects-toVegf connects-toIl 10 connects-toProstaglandins connects-toRenin connects-toZinc connects-toHepcidin connects-toSelenium connects-toLeptin connects-toAdiponectin connects-toResistin connects-toIl 4 connects-toSars Cov 2 connects-toIl 12 connects-toIl 13 connects-toIl 5 connects-toIl 23 connects-toIge connects-toSars Cov 2 connects-toDendritic Cell connects-toC5Ar1 connects-toFactor H connects-toC1 Esterase Inhibitor connects-toTransferrin connects-toTslp connects-toErythropoietin connects-toHistamine connects-toPeriostin connects-toMelatonin connects-toProlactin connects-toTestosterone connects-toSerotonin connects-toOxytocin connects-toVasopressin connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toPotassium connects-toCalcium connects-toPhosphorus connects-toChloride connects-toSulfur connects-toNitrogen connects-toCarbon connects-toHydrogen connects-toPd 1 connects-toGlp 1 connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin