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ptsd
PTSD
PTSD (7-10% lifetime risk after trauma) involves amygdala hyperreactivity, hippocampal atrophy, noradrenergic hyperarousal, and hypocortisolemia; first-line: trauma-focused CBT and SSRIs (sertraline, paroxetine); prazosin (α1 antagonist) reduces nightmares.
Entry Metadata
| Field | Value |
|---|---|
| ID | ptsd |
| Name | PTSD |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
Sources
- Yehuda R, Hoge CW, McFarlane AC, et al. Post-traumatic stress disorder. Nat Rev Dis Primers. 2015;1:15057. · PubMed 27189040
- Foa EB, McLean CP. The efficacy of exposure therapy for anxiety and related disorders and its underlying mechanisms: the emotional processing theory. Annu Rev Clin Psychol. 2016;12:1-28. · PubMed 26928206
- Mitchell JM, Bogenschutz M, Lilienstein A, et al. MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 trial. Nat Med. 2021;27(6):1025-1033.