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orexin
Orexin
Orexin (hypocretin-A/B) neuropeptides from lateral hypothalamic neurons maintain wakefulness by activating LC, raphe, TMN, and basal forebrain; orexin neuron loss causes narcolepsy type 1; OX1R/OX2R antagonists (suvorexant, lemborexant, daridorexant) treat insomnia.
Entry Metadata
| Field | Value |
|---|---|
| ID | orexin |
| Name | Orexin |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- de Lecea L, Kilduff TS, Peyron C, et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA. 1998;95(1):322-327. · PubMed 9419374
- Sakurai T, Amemiya A, Ishii M, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998;92(4):573-585. · PubMed 9491897
- Scammell TE. Narcolepsy. N Engl J Med. 2015;373(27):2654-2662. · PubMed 26716917