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insomnia-disorder
Insomnia Disorder
Insomnia disorder (10-30% chronic) involves VLPO failure to suppress arousal centers and cortical hyperarousal; first-line: CBT-I (sleep restriction, stimulus control, cognitive restructuring); pharmacotherapy: DORAs (suvorexant, lemborexant), Z-drugs, low-dose doxepin.
Entry Metadata
| Field | Value |
|---|---|
| ID | insomnia-disorder |
| Name | Insomnia Disorder |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
Sources
- Riemann D, Baglioni C, Bassetti C, et al. European guideline for the diagnosis and treatment of insomnia. J Sleep Res. 2017;26(6):675-700. · PubMed 28875581
- Trauer JM, Qian MY, Doyle JS, Rajaratnam SM, Cunnington D. Cognitive behavioral therapy for chronic insomnia: a systematic review and meta-analysis. Ann Intern Med. 2015;163(3):191-204. · PubMed 26054060
- Herring WJ, Snyder E, Budd K, et al. Orexin receptor antagonism for treatment of insomnia. Sci Transl Med. 2012;4(129):129ra45. · PubMed 22491949