Atlas One · Host Biology · Scale 07 — System

Insomnia Disorder

Insomnia disorder (10-30% chronic) involves VLPO failure to suppress arousal centers and cortical hyperarousal; first-line: CBT-I (sleep restriction, stimulus control, cognitive restructuring); pharmacotherapy: DORAs (suvorexant, lemborexant), Z-drugs, low-dose doxepin.

Also known as: insomnia disorder, insomnia, chronic insomnia, sleep-onset insomnia, sleep-maintenance insomnia, CBT-I, suvorexant, DORA, ISI, ISQ, Insomnia Severity Index, sleep restriction

Scale 07 — SystemScale

draftStatus

2026-06-08Last Reviewed

This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.

insomnia-disorder

Insomnia Disorder

Insomnia disorder (10-30% chronic) involves VLPO failure to suppress arousal centers and cortical hyperarousal; first-line: CBT-I (sleep restriction, stimulus control, cognitive restructuring); pharmacotherapy: DORAs (suvorexant, lemborexant), Z-drugs, low-dose doxepin.

Entry Metadata

Field	Value
ID	insomnia-disorder
Name	Insomnia Disorder
Status	draft
Last reviewed	2026-06-08
Atlas	01-human
Scale	07-system

Cross-Atlas Connections

connects-toOrexin connects-toGaba connects-toSerotonin connects-toHistamine targetsBrain connects-toAdenosine connects-toCortisol connects-toMelatonin connects-toGrowth Hormone connects-toLewy Body Dementia connects-toMajor Depressive Disorder connects-toGeneralized Anxiety Disorder connects-toNarcolepsy connects-toPtsd connects-toBipolar Disorder connects-toFibromyalgia connects-toObesity connects-toAlzheimers Disease connects-toNervous System connects-toType 2 Diabetes connects-toAlcohol Use Disorder connects-toAcetylcholine connects-toHypertension connects-toImmune System connects-toThyroid connects-toNorepinephrine connects-toHippocampus connects-toAstrocyte connects-toMagnesium connects-toSynapse connects-toPhoton connects-toHeart connects-toNeuron connects-toIron connects-toMicroglia connects-toAdrenal Gland connects-toVitamin D connects-toLarge Intestine connects-toCalcium connects-toStomach connects-toPancreas connects-toReproductive System connects-toAntibody connects-toCardiovascular System connects-toGut Microbiome connects-toIl 6 connects-toParkinsons Disease connects-toNeuropathic Pain connects-toNlrp3 Inflammasome connects-toStroke connects-toT Helper Cell connects-toNf Kb connects-toPanic Disorder connects-toCkd connects-toHeart Failure connects-toMigraine connects-toSchizophrenia connects-toAtherosclerosis connects-toCopd connects-toWound Healing connects-toEndocrine System connects-toDigestive System connects-toAttention Deficit Hyperactivity Disorder connects-toRespiratory System connects-toMusculoskeletal System connects-toIntegumentary System connects-toLymphatic System connects-toRenal System connects-toMagnesium Dietary connects-toAshwagandha connects-toObsessive Compulsive Disorder connects-toSocial Anxiety Disorder connects-toStimulant Use Disorder connects-toCannabis Use Disorder connects-toBinge Eating Disorder connects-toInternet Gaming Disorder connects-toCardiac Conduction System connects-toOpioid Use Disorder connects-toEpilepsy connects-toAsthma connects-toCovid 19 Disease connects-toIron Deficiency Anemia connects-toReproductive System connects-toMyocardium connects-toCrh connects-toIl 1B connects-toTnf Alpha connects-toGlutamate connects-toDopamine connects-toGhrelin connects-toProstaglandins connects-toProgesterone connects-toEndocannabinoid connects-toEstrogen connects-toThyroid Hormones connects-toVasopressin connects-toGlucocorticoid Receptor connects-toBdnf connects-toMtor connects-toTlr4 connects-toNtrk connects-toNpy connects-toAkt connects-toGalectin 3 connects-toNfe2L2 connects-toGsk 3B connects-toStat3 connects-toCgas Sting connects-toFoxo connects-toStat1 connects-toJak1 2 connects-toHif 1Alpha connects-toS100A8 A9 connects-toPik3Ca connects-toAmpk connects-toAutophagy connects-toDnmt3A connects-toSrc Kinase connects-toCcr5 connects-toCxcl12 connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toLeptin connects-toNitric Oxide connects-toTestosterone connects-toInsulin connects-toIl 10 connects-toXanthine Oxidase connects-toCholesterol connects-toAldosterone connects-toGlp 1 connects-toIl 4 connects-toIl 13 connects-toZinc connects-toCopper connects-toAdiponectin connects-toResistin connects-toAstrocyte connects-toGeneralized Anxiety Disorder connects-toType 2 Diabetes connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toT Cytotoxic Cell connects-toNatural Killer Cell connects-toComplement C5 connects-toC5Ar1 connects-toDendritic Cell connects-toTslp connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toErythropoietin connects-toPeriostin connects-toFactor H connects-toProlactin connects-toOxytocin connects-toSelenium connects-toIodine connects-toSodium connects-toPotassium connects-toPhosphorus connects-toChloride connects-toSulfur connects-toNitrogen connects-toOxygen connects-toCarbon connects-toHydrogen connects-toPd 1 connects-toAngiotensin Ii connects-toVegf connects-toWnt Beta Catenin connects-toRankl connects-toSmad4 connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAndrogen Receptor connects-toAdrenomedullin connects-toOsteopontin connects-toFgfr connects-toEpinephrine

Sources