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il-1b
IL-1β
IL-1β (IL1B; chr2q14.1) is a pro-inflammatory cytokine processed by NLRP3 inflammasome/caspase-1; signals via IL-1R1→NF-κB driving fever, acute-phase response, and synovitis. Approved blockers: anakinra (FDA 2001), canakinumab (FDA 2013), rilonacept (FDA 2021).
Entry Metadata
| Field | Value |
|---|---|
| ID | il-1b |
| Name | IL-1β |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Dinarello CA. Overview of the IL-1 family in innate inflammation and acquired immunity. Immunol Rev. 2018;281(1):8-27. · PubMed 29247995
- Ridker PM, Everett BM, Thuren T, et al. Antiinflammatory therapy with canakinumab for atherosclerotic disease. N Engl J Med. 2017;377(12):1119-1131. · PubMed 28845751
- Klein AL, Imazio M, Cremer P, et al. Phase 3 trial of interleukin-1 trap rilonacept in recurrent pericarditis. N Engl J Med. 2021;384(1):31-41. · PubMed 33405895