Atlas One · Host Biology · Scale 07 — System

Giant Cell Arteritis

Giant cell arteritis (GCA) is the most common primary vasculitis in adults >50; granulomatous inflammation of temporal arteries and aortic branches; IL-6 and IL-1β drive pathogenesis. Tocilizumab (anti-IL-6R; GiACTA; FDA May 2017) is the first approved steroid-sparing therapy.

Also known as: GCA, giant cell arteritis, temporal arteritis, cranial arteritis, Horton disease, polymyalgia rheumatica

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
giant-cell-arteritis

Giant Cell Arteritis

Giant cell arteritis (GCA) is the most common primary vasculitis in adults >50; granulomatous inflammation of temporal arteries and aortic branches; IL-6 and IL-1β drive pathogenesis. Tocilizumab (anti-IL-6R; GiACTA; FDA May 2017) is the first approved steroid-sparing therapy.

Entry Metadata

FieldValue
IDgiant-cell-arteritis
NameGiant Cell Arteritis
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toIl 1B connects-toIl 6 connects-toIl 17A connects-toIfn Gamma connects-toMacrophage connects-toT Helper Cell connects-toSmooth Muscle Cell connects-toAnca Vasculitis connects-toEndothelial Cell connects-toStroke connects-toEye connects-toCardiovascular System connects-toDendritic Cell connects-toRheumatoid Arthritis connects-toIl 12 connects-toJak2 connects-toVegf connects-toHeart connects-toSystemic Lupus Erythematosus connects-toCortisol connects-toNervous System connects-toImmune System connects-toMusculoskeletal System connects-toFibroblast connects-toRegulatory T Cell connects-toErythrocyte connects-toCollagen connects-toTnf Alpha connects-toOxygen connects-toBrain connects-toPdgf connects-toIron connects-toSkin connects-toFibrosis connects-toPhoton connects-toPeripheral Nerve connects-toCalcium connects-toElectron connects-toLarge Intestine connects-toLung connects-toAntibody connects-toNeuron connects-toAdrenal Gland connects-toPlatelet connects-toOsteoporosis connects-toVaricella Zoster Virus connects-toIl 23 connects-toNatural Killer Cell connects-toType 2 Diabetes connects-toJak1 2 connects-toCmml connects-toHeart Failure connects-toStat3 connects-toVenous Thromboembolism connects-toSepsis connects-toAnemia Of Chronic Disease connects-toPneumocystis Jirovecii connects-toMajor Depressive Disorder connects-toAspergillus Fumigatus connects-toWound Healing connects-toGeneralized Anxiety Disorder connects-toEndocrine System connects-toDigestive System connects-toIntegumentary System connects-toRespiratory System connects-toRenal System connects-toLymphatic System connects-toCorticosteroids connects-toAspirin connects-toVitamin D connects-toArterial Wall connects-toCancer Chemotherapy connects-toAtherosclerosis connects-toTargeted Therapy connects-toCheckpoint Inhibitors connects-toGerminal Center connects-toMyocardium connects-toCortical Bone connects-toFibrinogen connects-toMds connects-toVaricella Zoster Virus connects-toCovid 19 Disease connects-toEndothelin 1 connects-toNotch connects-toT Cytotoxic Cell connects-toNlrp3 Inflammasome connects-toCcl2 connects-toHif 1Alpha connects-toMhc Class Ii connects-toS100A8 A9 connects-toTgf Beta connects-toTlr4 connects-toMtor connects-toCxcl12 connects-toGlucocorticoid Receptor connects-toAngiopoietin connects-toProstaglandins connects-toNf Kb connects-toIl 10 connects-toErk1 2 connects-toMyd88 connects-toPd 1 connects-toPerforin connects-toStat1 connects-toAkt connects-toGalectin 3 connects-toSmad4 connects-toCgas Sting connects-toPik3Ca connects-toFoxo connects-toCdk4 6 connects-toGsk 3B connects-toSrc Kinase connects-toAmpk connects-toAutophagy connects-toCcr5 connects-toDnmt3A connects-toCalcineurin connects-toIl 33 connects-toComplement C3 connects-toAdenosine connects-toArid1A connects-toOsteopontin connects-toType I Interferon connects-toCtla 4 connects-toTroponin Complex connects-toHemoglobin connects-toNitric Oxide connects-toIl 2 connects-toXanthine Oxidase connects-toHepcidin connects-toInsulin connects-toCholesterol connects-toRankl connects-toPotassium connects-toIl 4 connects-toIl 13 connects-toLeptin connects-toAdiponectin connects-toResistin connects-toNeutrophil connects-toB Cell connects-toPlasma Cell connects-toIl 5 connects-toIge connects-toMast Cell connects-toHistamine connects-toSelenium connects-toC5Ar1 connects-toFactor H connects-toTransferrin connects-toComplement C5 connects-toC1 Esterase Inhibitor connects-toPeriostin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toMelatonin connects-toTestosterone connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSerotonin connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toZinc connects-toPhosphorus connects-toChloride connects-toSulfur connects-toNitrogen connects-toCarbon connects-toHydrogen connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toFibronectin connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr connects-toEpinephrine connects-toRenin