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foxo
FOXO
Transcription factors (FOXO1/3/4) integrating PI3K-AKT, mTOR, and oxidative stress with cell cycle arrest and longevity; AKT phosphorylation → FOXO nuclear exclusion → loss of p21, BIM, PUMA. PI3K inhibition → FOXO re-activation → tumor suppression and longevity programs.
Entry Metadata
| Field | Value |
|---|---|
| ID | foxo |
| Name | FOXO |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Brunet A, Bonni A, Zigmond MJ, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 1999;96(6):857-868. · PubMed 10102273
- Calnan DR, Brunet A. The FoxO code. Oncogene. 2008;27(16):2276-2288. · PubMed 18391970
- Eijkelenboom A, Burgering BM. FOXOs: signalling integrators for homeostasis maintenance. Nat Rev Mol Cell Biol. 2013;14(2):83-97. · PubMed 23325358