Atlas One · Host Biology · Scale 03 — Molecular

FOXO1

FOXO1 (FKHR) is a forkhead TF inactivated by AKT phosphorylation → cytoplasmic sequestration; nuclear FOXO1 induces p27, FasL, and antioxidant genes; PAX3-FOXO1 t(2;13) and PAX7-FOXO1 t(1;13) are defining oncogenic fusions in alveolar rhabdomyosarcoma.

Also known as: FOXO1, FKHR, forkhead box O1, PAX3-FOXO1, PAX7-FOXO1, FOXO1 rhabdomyosarcoma, FOXO1 AKT, FKHR alveolar RMS

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
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foxo1

FOXO1

FOXO1 (FKHR) is a forkhead TF inactivated by AKT phosphorylation → cytoplasmic sequestration; nuclear FOXO1 induces p27, FasL, and antioxidant genes; PAX3-FOXO1 t(2;13) and PAX7-FOXO1 t(1;13) are defining oncogenic fusions in alveolar rhabdomyosarcoma.

Entry Metadata

FieldValue
IDfoxo1
NameFOXO1
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toAkt connects-toMyc connects-toMet connects-toPten connects-toFoxo connects-toRhabdomyosarcoma connects-toCyclin D1

Sources