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cyclin-d1
Cyclin D1
Cell cycle G1/S accelerator; Wnt/RAS-MAPK/oncogene signaling → cyclin D1-CDK4/6 → Rb phosphorylation → E2F-S phase entry. Amplified in breast, HNSCC, and bladder cancers; cyclin D1-CDK4/6 complex is the direct molecular target of palbociclib, ribociclib, and abemaciclib.
Entry Metadata
| Field | Value |
|---|---|
| ID | cyclin-d1 |
| Name | Cyclin D1 |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Sherr CJ. G1 phase progression: cycling on cue. Cell. 1994;79(4):551-555. · PubMed 7954821
- Weinberg RA. The retinoblastoma protein and cell cycle control. Cell. 1995;81(3):323-330. · PubMed 7736585
- Dickson C, Fantl V, Gillett C, et al. Amplification of chromosome band 11q13 and a role for cyclin D1 in human breast cancer. Cancer Lett. 1995;90(1):43-50. · PubMed 7882378