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wnt-beta-catenin
Wnt/beta-catenin
Canonical Wnt pathway; Wnt ligands inhibit β-catenin destruction complex (APC/Axin/GSK-3β/CK1) → nuclear β-catenin → TCF/LEF target genes (MYC, CCND1). APC mutation initiates >80% of colorectal cancers; porcupine inhibitors block Wnt secretion for therapy.
Entry Metadata
| Field | Value |
|---|---|
| ID | wnt-beta-catenin |
| Name | Wnt/beta-catenin |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Clevers H. Wnt/beta-catenin signaling in development and disease. Cell. 2006;127(3):469-480. · PubMed 17081971
- Nusse R, Clevers H. Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. Cell. 2017;169(6):985-999. · PubMed 28575679
- Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 1990;61(5):759-767. · PubMed 2188735