Atlas One · Host Biology · Scale 07 — System

Breast Cancer

Most common cancer in women; driven by ER/PR hormone signaling, HER2 amplification, and basal TNBC subtypes. BRCA1/2 mutations drive hereditary cases; CDK4/6 inhibitors (palbociclib), anti-HER2 (trastuzumab), PARP inhibitors (olaparib), and immunotherapy are mainstays.

Also known as: breast carcinoma, HR+ breast cancer, HER2+ breast cancer, TNBC, triple-negative breast cancer, luminal A, luminal B, invasive ductal carcinoma, invasive lobular carcinoma, DCIS

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
breast-cancer

Breast Cancer

Most common cancer in women; driven by ER/PR hormone signaling, HER2 amplification, and basal TNBC subtypes. BRCA1/2 mutations drive hereditary cases; CDK4/6 inhibitors (palbociclib), anti-HER2 (trastuzumab), PARP inhibitors (olaparib), and immunotherapy are mainstays.

Entry Metadata

FieldValue
IDbreast-cancer
NameBreast Cancer
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toHer2 connects-toPik3Ca connects-toBrca1 connects-toCdk4 6 connects-toEstrogen connects-toProgesterone connects-toRankl connects-toCxcl12 connects-toAngiopoietin connects-toEndometrial Cancer connects-toOvarian Cancer connects-toOsteoblast connects-toHereditary Breast Ovarian Cancer connects-toLi Fraumeni Syndrome connects-toT Cytotoxic Cell connects-toCowden Syndrome connects-toPhoton connects-toProstate Cancer connects-toBrca2 connects-toPd 1 connects-toLymphatic System connects-toBrain connects-toFibroblast connects-toObesity connects-toLiver connects-toMacrophage connects-toAlcohol Use Disorder connects-toLung connects-toAdipocyte connects-toOsteoclast connects-toCalcium connects-toBone Marrow connects-toNatural Killer Cell connects-toCopper connects-toSkin connects-toFibrosis connects-toElectron connects-toEye connects-toPlatelet connects-toNeuron connects-toHeart connects-toReproductive System connects-toAntibody connects-toNeutrophil connects-toStomach connects-toP53 connects-toHeart Failure connects-toRegulatory T Cell connects-toPalb2 connects-toMtor connects-toMyc connects-toNf Kb connects-toVenous Thromboembolism connects-toSepsis connects-toOsteoporosis connects-toAnemia Of Chronic Disease connects-toMajor Depressive Disorder connects-toNeuropathic Pain connects-toStroke connects-toAspergillus Fumigatus connects-toEndocrine System connects-toWound Healing connects-toGeneralized Anxiety Disorder connects-toMusculoskeletal System connects-toRespiratory System connects-toNervous System connects-toCardiovascular System connects-toIntegumentary System connects-toDigestive System connects-toTargeted Therapy connects-toImmune System connects-toSulforaphane connects-toCancer Chemotherapy connects-toCortical Bone connects-toMyocardium connects-toHereditary Diffuse Gastric Cancer connects-toGerminal Center connects-toPancreatic Cancer connects-toHepatic Lobule connects-toAml connects-toMelanoma connects-toEpilepsy connects-toPeripheral Nerve connects-toInflammatory Bowel Disease connects-toAkt connects-toHif 1Alpha connects-toVegf connects-toCyclin D1 connects-toTgf Beta connects-toCcl2 connects-toCdh1 connects-toRad51 connects-toAndrogen Receptor connects-toCgas Sting connects-toFgfr connects-toNotch connects-toPten connects-toE2F1 connects-toErk1 2 connects-toIgf 1 connects-toWnt Beta Catenin connects-toMdm2 connects-toSmad4 connects-toBcl 2 connects-toStat3 connects-toGalectin 3 connects-toStat1 connects-toEzh2 connects-toFoxo connects-toPerforin connects-toS100A8 A9 connects-toGsk 3B connects-toSrc Kinase connects-toDnmt3A connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toIl 6 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toMhc Class Ii connects-toAxl Receptor connects-toLeptin connects-toTroponin Complex connects-toIl 2 connects-toHemoglobin connects-toProstaglandins connects-toIl 10 connects-toXanthine Oxidase connects-toIl 4 connects-toIron connects-toAdiponectin connects-toIl 13 connects-toMacrophage connects-toFibroblast connects-toResistin connects-toLiver connects-toAdipocyte connects-toIfn Gamma connects-toIl 12 connects-toType I Interferon connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toB Cell connects-toT Helper Cell connects-toComplement C5 connects-toC5Ar1 connects-toDendritic Cell connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toPeriostin connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toZinc connects-toPotassium connects-toPhosphorus connects-toChloride connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toGlp 1 connects-toAngiotensin Ii connects-toFibronectin connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toEpinephrine connects-toRenin connects-toMyostatin connects-toCortisol connects-toGlucagon

Sources