Atlas One · Host Biology · Scale 07 — System

Ovarian Cancer

HGSOC accounts for ~70% of ovarian cancer; BRCA1/2 mutations in ~15-20%; TP53 mutations in ~96%; olaparib and niraparib approved as maintenance; bevacizumab improves PFS; carboplatin+paclitaxel is standard frontline; PARP inhibitor maintenance is standard for HRD+ tumors.

Also known as: ovarian cancer, HGSOC, high-grade serous ovarian cancer, LGSOC, clear cell ovarian cancer, epithelial ovarian cancer, EOC, ovarian carcinoma

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
ovarian-cancer

Ovarian Cancer

HGSOC accounts for ~70% of ovarian cancer; BRCA1/2 mutations in ~15-20%; TP53 mutations in ~96%; olaparib and niraparib approved as maintenance; bevacizumab improves PFS; carboplatin+paclitaxel is standard frontline; PARP inhibitor maintenance is standard for HRD+ tumors.

Entry Metadata

FieldValue
IDovarian-cancer
NameOvarian Cancer
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toBrca1 connects-toPd 1 connects-toVegf connects-toMtor connects-toHereditary Breast Ovarian Cancer connects-toP53 connects-toBrca2 connects-toOvarian Clear Cell Carcinoma connects-toReproductive System connects-toEndometrial Cancer connects-toLynch Syndrome connects-toBreast Cancer connects-toMacrophage connects-toMesothelioma connects-toGorlin Syndrome connects-toPeutz Jeghers Syndrome connects-toEstrogen connects-toT Cytotoxic Cell connects-toLiver connects-toRad51 connects-toDigestive System connects-toVenous Thromboembolism connects-toArid1A connects-toAtm connects-toFibroblast connects-toAlbumin connects-toRegulatory T Cell connects-toNatural Killer Cell connects-toLarge Intestine connects-toLung connects-toDendritic Cell connects-toCalcium connects-toKidney connects-toAdipocyte connects-toPhoton connects-toSpleen connects-toPlatelet connects-toNeuron connects-toElectron connects-toMagnesium connects-toAntibody connects-toNeutrophil connects-toErythrocyte connects-toCardiomyocyte connects-toStat3 connects-toT Helper Cell connects-toPalb2 connects-toEndothelial Cell connects-toPancreatic Cancer connects-toCxcl12 connects-toSepsis connects-toMast Cell connects-toNf Kb connects-toCkd connects-toAnemia Of Chronic Disease connects-toOsteoporosis connects-toHeart Failure connects-toMajor Depressive Disorder connects-toNeuropathic Pain connects-toAml connects-toGeneralized Anxiety Disorder connects-toWound Healing connects-toRespiratory System connects-toEndocrine System connects-toLymphatic System connects-toNervous System connects-toIntegumentary System connects-toTargeted Therapy connects-toRenal System connects-toCardiovascular System connects-toCancer Chemotherapy connects-toCheckpoint Inhibitors connects-toImmune System connects-toProstate Cancer connects-toGerminal Center connects-toGastric Cancer connects-toIntestinal Epithelium connects-toHepatic Lobule connects-toWt1 connects-toMds connects-toColorectal Cancer connects-toArterial Wall connects-toMyc connects-toCdk4 6 connects-toNotch connects-toAkt connects-toHif 1Alpha connects-toEzh2 connects-toIl 6 connects-toTgf Beta connects-toCgas Sting connects-toCaspase 3 connects-toPten connects-toMlh1 connects-toKras connects-toPik3Ca connects-toCcl2 connects-toErk1 2 connects-toE2F1 connects-toHer2 connects-toJak1 2 connects-toRb1 connects-toMdm2 connects-toGalectin 3 connects-toSmad4 connects-toCdkn2A connects-toStat1 connects-toFoxo connects-toPerforin connects-toGsk 3B connects-toS100A8 A9 connects-toSrc Kinase connects-toDnmt3A connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toIl 1B connects-toEndothelin 1 connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toMhc Class Ii connects-toAxl Receptor connects-toBcl 2 connects-toIl 2 connects-toHemoglobin connects-toTroponin Complex connects-toSmall Intestine connects-toIl 10 connects-toXanthine Oxidase connects-toIl 4 connects-toIron connects-toNitric Oxide connects-toIl 13 connects-toLeptin connects-toHepcidin connects-toAdiponectin connects-toResistin connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toPlasma Cell connects-toIl 23 connects-toIge connects-toB Cell connects-toVitamin D connects-toC5Ar1 connects-toComplement C5 connects-toFactor H connects-toTransferrin connects-toTslp connects-toPeriostin connects-toHistamine connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toErythropoietin connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toCopper connects-toPotassium connects-toPhosphorus connects-toCarbon connects-toChloride connects-toHydrogen connects-toNitrogen connects-toOxygen connects-toSulfur connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr

Sources