Prolactin

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prolactin

23 kDa pituitary lactotroph hormone suppressed by tuberoinfundibular dopamine (TIDA-D2R); suckling and TRH stimulate secretion; drives lactation (JAK2/STAT5) and suppresses GnRH → infertility; treated with cabergoline (D2 agonist) for prolactinoma.

Entry Metadata

Field	Value
ID	prolactin
Name	Prolactin
Status	draft
Last reviewed	2026-06-08
Atlas	01-human
Scale	03-molecular

Cross-Atlas Connections

modulated-byDopamine modulated-bySerotonin connects-toOxytocin connects-toSchizophrenia connects-toMajor Depressive Disorder expressed-byBrain

Sources

Freeman ME, Kanyicska B, Lerant A, Nagy G. Prolactin: structure, function, and regulation of secretion. Physiol Rev. 2000;80(4):1523-1631. · PubMed 11015620
Melmed S, Casanueva FF, Hoffman AR, et al. Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(2):273-288. · PubMed 21296991
Bole-Feysot C, Goffin V, Edery M, Binart N, Kelly PA. Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev. 1998;19(3):225-268. · PubMed 9626554