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schizophrenia
Schizophrenia
Schizophrenia (1% lifetime risk) is a severe psychotic disorder with positive symptoms (hallucinations, delusions), negative symptoms (avolition, flat affect), and cognitive deficits; mesolimbic dopamine D2 hyperactivity drives psychosis; all antipsychotics block D2 receptors.
Entry Metadata
| Field | Value |
|---|---|
| ID | schizophrenia |
| Name | Schizophrenia |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
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connects-toVitamin D
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connects-toMusculoskeletal System
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connects-toInfluenza A
connects-toOmega 3 Fatty Acids
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connects-toPtsd
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connects-toInsomnia Disorder
connects-toHuntingtons Disease
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connects-toMyocardium
connects-toBreast Cancer
connects-toCovid 19 Disease
connects-toNarcolepsy
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connects-toEndocannabinoid
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connects-toTnf Alpha
connects-toIl 1B
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connects-toNorepinephrine
connects-toNitric Oxide
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connects-toType I Interferon
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connects-toAkt
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connects-toGlp 1
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connects-toErk1 2
connects-toNtrk
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connects-toNfe2L2
connects-toGalectin 3
connects-toJak1 2
connects-toPten
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connects-toStat1
connects-toFoxo
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connects-toS100A8 A9
connects-toDnmt3A
connects-toAmpk
connects-toAutophagy
connects-toSrc Kinase
connects-toCcr5
connects-toComplement C5
connects-toCxcl12
connects-toIl 33
connects-toIl 17A
connects-toEstrogen
connects-toLeptin
connects-toXanthine Oxidase
connects-toAngiotensin Ii
connects-toProgesterone
connects-toIron
connects-toProstaglandins
connects-toTroponin Complex
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connects-toIl 13
connects-toResistin
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connects-toMagnesium
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connects-toIl 12
connects-toIl 23
connects-toIl 5
connects-toT Cytotoxic Cell
connects-toDendritic Cell
connects-toIge
connects-toMast Cell
connects-toC5Ar1
connects-toNatural Killer Cell
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connects-toFactor H
connects-toRegulatory T Cell
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connects-toErythropoietin
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connects-toTestosterone
connects-toTransferrin
connects-toVasopressin
connects-toSelenium
connects-toIodine
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connects-toPd 1
connects-toWnt Beta Catenin
connects-toRankl
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connects-toIl 2
connects-toFibronectin
connects-toNotch
connects-toIgf 1
connects-toActivin A
connects-toTgf Beta
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAldosterone
connects-toAndrogen Receptor
connects-toAdrenomedullin
connects-toOsteopontin
connects-toFgfr
connects-toEpinephrine
connects-toRenin
connects-toMyostatin
connects-toAngiopoietin
connects-toGhrelin
Sources
- Howes OD, Kapur S. The dopamine hypothesis of schizophrenia: version III—the final common pathway. Schizophr Bull. 2009;35(3):549-562. · PubMed 19325164
- Moghaddam B, Javitt D. From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment. Neuropsychopharmacology. 2012;37(1):4-15. · PubMed 21956446
- Leucht S, Cipriani A, Spineli L, et al. Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. Lancet. 2013;382(9896):951-962. · PubMed 23810019