Atlas One · Host Biology · Scale 07 — System

Schizophrenia

Schizophrenia (1% lifetime risk) is a severe psychotic disorder with positive symptoms (hallucinations, delusions), negative symptoms (avolition, flat affect), and cognitive deficits; mesolimbic dopamine D2 hyperactivity drives psychosis; all antipsychotics block D2 receptors.

Also known as: schizophrenia, psychosis, positive symptoms, negative symptoms, dopamine hypothesis, NMDA hypofunction, antipsychotic, clozapine, haloperidol, schizophrenia spectrum

Scale 07 — SystemScale
draftStatus
2026-06-08Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
schizophrenia

Schizophrenia

Schizophrenia (1% lifetime risk) is a severe psychotic disorder with positive symptoms (hallucinations, delusions), negative symptoms (avolition, flat affect), and cognitive deficits; mesolimbic dopamine D2 hyperactivity drives psychosis; all antipsychotics block D2 receptors.

Entry Metadata

FieldValue
IDschizophrenia
NameSchizophrenia
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toDopamine connects-toGlutamate connects-toGaba connects-toSerotonin targetsBrain connects-toProlactin connects-toHistamine connects-toNeuron connects-toBipolar Disorder connects-toHippocampus connects-toMicroglia connects-toAutism Spectrum Disorder connects-toAstrocyte connects-toMajor Depressive Disorder connects-toEpilepsy connects-toOligodendrocyte connects-toBdnf connects-toCannabis Use Disorder connects-toAcetylcholine connects-toSynapse connects-toImmune System connects-toCardiovascular System connects-toComplement C3 connects-toPlacenta connects-toGut Microbiome connects-toCalcium connects-toIl 6 connects-toCortisol connects-toMagnesium connects-toAdrenal Gland connects-toLarge Intestine connects-toZinc connects-toHeart connects-toAdipocyte connects-toPhoton connects-toEye connects-toVitamin D connects-toNeutrophil connects-toPancreas connects-toPotassium connects-toAntibody connects-toToxoplasma Gondii connects-toReproductive System connects-toInsulin connects-toCardiomyocyte connects-toObesity connects-toType 2 Diabetes connects-toT Helper Cell connects-toMelatonin connects-toNlrp3 Inflammasome connects-toAlcohol Use Disorder connects-toStroke connects-toVenous Thromboembolism connects-toParkinsons Disease connects-toSepsis connects-toHeart Failure connects-toCopd connects-toOsteoporosis connects-toObsessive Compulsive Disorder connects-toDigestive System connects-toGeneralized Anxiety Disorder connects-toNervous System connects-toEndocrine System connects-toRespiratory System connects-toRenal System connects-toMusculoskeletal System connects-toIntegumentary System connects-toInfluenza A connects-toOmega 3 Fatty Acids connects-toFluoxetine connects-toMetformin connects-toPtsd connects-toBorderline Personality Disorder connects-toInsomnia Disorder connects-toHuntingtons Disease connects-toAlzheimers Disease connects-toCardiac Conduction System connects-toMyocardium connects-toBreast Cancer connects-toCovid 19 Disease connects-toNarcolepsy connects-toNsclc connects-toEndocannabinoid connects-toOxytocin connects-toTnf Alpha connects-toIl 1B connects-toIfn Gamma connects-toNorepinephrine connects-toNitric Oxide connects-toGsk 3B connects-toType I Interferon connects-toMhc Class Ii connects-toAdenosine connects-toCalcineurin connects-toAkt connects-toMtor connects-toGlp 1 connects-toPik3Ca connects-toCrh connects-toErk1 2 connects-toNtrk connects-toTlr4 connects-toNfe2L2 connects-toGalectin 3 connects-toJak1 2 connects-toPten connects-toStat3 connects-toCgas Sting connects-toStat1 connects-toFoxo connects-toHif 1Alpha connects-toS100A8 A9 connects-toDnmt3A connects-toAmpk connects-toAutophagy connects-toSrc Kinase connects-toCcr5 connects-toComplement C5 connects-toCxcl12 connects-toIl 33 connects-toIl 17A connects-toEstrogen connects-toLeptin connects-toXanthine Oxidase connects-toAngiotensin Ii connects-toProgesterone connects-toIron connects-toProstaglandins connects-toTroponin Complex connects-toVegf connects-toCholesterol connects-toIl 10 connects-toCopper connects-toIl 4 connects-toIl 13 connects-toResistin connects-toAdiponectin connects-toMagnesium connects-toZinc connects-toIl 12 connects-toIl 23 connects-toIl 5 connects-toT Cytotoxic Cell connects-toDendritic Cell connects-toIge connects-toMast Cell connects-toC5Ar1 connects-toNatural Killer Cell connects-toC1 Esterase Inhibitor connects-toFactor H connects-toRegulatory T Cell connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toPeriostin connects-toTestosterone connects-toTransferrin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toPhosphorus connects-toSulfur connects-toChloride connects-toNitrogen connects-toCarbon connects-toOxygen connects-toHydrogen connects-toNf Kb connects-toPd 1 connects-toWnt Beta Catenin connects-toRankl connects-toSmad4 connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toAdrenomedullin connects-toOsteopontin connects-toFgfr connects-toEpinephrine connects-toRenin connects-toMyostatin connects-toAngiopoietin connects-toGhrelin