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schizophrenia
Schizophrenia
Schizophrenia (1% lifetime risk) is a severe psychotic disorder with positive symptoms (hallucinations, delusions), negative symptoms (avolition, flat affect), and cognitive deficits; mesolimbic dopamine D2 hyperactivity drives psychosis; all antipsychotics block D2 receptors.
Entry Metadata
| Field | Value |
|---|---|
| ID | schizophrenia |
| Name | Schizophrenia |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
Sources
- Howes OD, Kapur S. The dopamine hypothesis of schizophrenia: version III—the final common pathway. Schizophr Bull. 2009;35(3):549-562. · PubMed 19325164
- Moghaddam B, Javitt D. From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment. Neuropsychopharmacology. 2012;37(1):4-15. · PubMed 21956446
- Leucht S, Cipriani A, Spineli L, et al. Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. Lancet. 2013;382(9896):951-962. · PubMed 23810019