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progesterone
Progesterone
C21 progestogen secreted by corpus luteum via CYP11A1/3β-HSD; prepares endometrium for implantation and maintains pregnancy; metabolized to allopregnanolone (GABA-A PAM); PR antagonism by mifepristone induces abortion; deficiency causes luteal phase dysfunction.
Entry Metadata
| Field | Value |
|---|---|
| ID | progesterone |
| Name | Progesterone |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Lydon JP, DeMayo FJ, Funk CR, et al. Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev. 1995;9(18):2266-2278. · PubMed 7557380
- Meltzer-Brody S, Colquhoun H, Riesenberg R, et al. Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials. Lancet. 2018;392(10152):1058-1070. · PubMed 30177236
- Schindler AE, Campagnoli C, Druckmann R, et al. Classification and pharmacology of progestins. Maturitas. 2003;46 Suppl 1:S7-16. · PubMed 14670641