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estrogen
Estrogen
C18 steroid from ovarian granulosa cells via CYP19A1; 17β-estradiol (E2) is the principal form; binds ERα/ERβ → reproductive cyclicity, bone density, serotonin modulation, and neuroprotection; estrogen deficiency causes osteoporosis; ERα drives ~70% of breast cancers.
Entry Metadata
| Field | Value |
|---|---|
| ID | estrogen |
| Name | Estrogen |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Nilsson S, Mäkelä S, Treuter E, et al. Mechanisms of estrogen action. Physiol Rev. 2001;81(4):1535-1565. · PubMed 11581496
- Gruber CJ, Tschugguel W, Schneeberger C, Huber JC. Production and actions of estrogens. N Engl J Med. 2002;346(5):340-352. · PubMed 11807149
- Soares CN. Depression and menopause: current knowledge and clinical recommendations for a critical window. Psychiatr Clin North Am. 2017;40(2):239-254. · PubMed 28477651