Atlas One · Host Biology · Scale 03 — Molecular

Serotonin

5-Hydroxytryptamine (5-HT); monoamine neurotransmitter synthesized from tryptophan by TPH1/TPH2 + AADC. ~95% in GI enterochromaffin cells; ~5% CNS (raphe nuclei). Regulates mood, sleep, GI motility, and platelet aggregation. Key SSRI target.

Also known as: 5-HT, 5-hydroxytryptamine, enteramine, serotonergic

Scale 03 — MolecularScale
draftStatus
2026-06-04Last Reviewed
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serotonin

Serotonin

5-Hydroxytryptamine (5-HT); monoamine neurotransmitter synthesized from tryptophan by TPH1/TPH2 + AADC. ~95% in GI enterochromaffin cells; ~5% CNS (raphe nuclei). Regulates mood, sleep, GI motility, and platelet aggregation. Key SSRI target.

Entry Metadata

FieldValue
IDserotonin
NameSerotonin
Statusdraft
Last reviewed2026-06-04
Atlas01-human
Scale03-molecular
Gene SymbolTPH2
UniprotP17752
NoteTPH1 (peripheral) and TPH2 (CNS) are the two tryptophan hydroxylase isoforms synthesizing 5-HT

Cross-Atlas Connections

expressed-byNeuron modulatesNervous System modulatesDigestive System modulated-bySerotonin Transporter modulated-bySt Johns Wort connects-toSchizophrenia connects-toMajor Depressive Disorder connects-toCgrp connects-toMigraine connects-toBipolar Disorder connects-toObsessive Compulsive Disorder connects-toGeneralized Anxiety Disorder connects-toPanic Disorder connects-toSocial Anxiety Disorder connects-toAlcohol Use Disorder connects-toInsomnia Disorder modulated-byOrexin connects-toAnorexia Nervosa connects-toBorderline Personality Disorder connects-toBulimia Nervosa connects-toStimulant Use Disorder connects-toPtsd connects-toGambling Disorder connects-toFibromyalgia connects-toSubstance P connects-toInternet Gaming Disorder connects-toBinge Eating Disorder connects-toNeuropathic Pain connects-toNarcolepsy modulatesMelatonin modulatesProlactin modulated-byEstrogen

Sources