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substance-p
Substance P
Substance P (11-aa tachykinin; NK1R/Gαq) is the primary neuropeptide mediator of slow pain, neurogenic inflammation, and emotional stress. Elevated CSF SP is a reproducible fibromyalgia biomarker. NK1R antagonists (aprepitant) are antiemetics; failed for depression.
Entry Metadata
| Field | Value |
|---|---|
| ID | substance-p |
| Name | Substance P |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Otsuka M, Yoshioka K. Neurotransmitter functions of mammalian tachykinins. Physiol Rev. 1993;73(2):229-308. · PubMed 8385466
- Russell IJ, Orr MD, Littman B, et al. Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome. Arthritis Rheum. 1994;37(11):1593-1601. · PubMed 7526868
- Kramer MS, Cutler N, Feighner J, et al. Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science. 1998;281(5383):1640-1645. · PubMed 9733503