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cgrp
CGRP
CGRP (37-aa neuropeptide encoded by CALCA via neuronal alternative splicing) mediates trigeminovascular pain and dural vasodilation in migraine; anti-CGRP mAbs (erenumab, fremanezumab) prevent migraine; gepants (rimegepant, ubrogepant) treat acute attacks.
Entry Metadata
| Field | Value |
|---|---|
| ID | cgrp |
| Name | CGRP |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Amara SG, Jonas V, Rosenfeld MG, Ong ES, Evans RM. Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature. 1982;298(5871):240-244. · PubMed 6285202
- Olesen J, Diener HC, Husstedt IW, et al. Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine. N Engl J Med. 2004;350(11):1104-1110. · PubMed 15014183
- Dodick DW, Ashina M, Brandes JL, et al. ARISE: A Phase 3 randomized trial of erenumab for episodic migraine. Cephalalgia. 2018;38(6):1026-1037. · PubMed 29471679