Atlas One · Host Biology · Scale 07 — System

Major Depressive Disorder

Major depressive disorder (280M affected) involves serotonergic/noradrenergic deficit, HPA dysregulation, neuroinflammation, and reduced BDNF neuroplasticity; SSRIs/SNRIs are first-line; ketamine (IV racemic or nasal esketamine) is the fastest-acting approved antidepressant.

Also known as: major depressive disorder, MDD, depression, unipolar depression, TRD, treatment-resistant depression, antidepressant, SSRI, SNRI, ketamine depression, esketamine

Scale 07 — SystemScale
draftStatus
2026-06-08Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
major-depressive-disorder

Major Depressive Disorder

Major depressive disorder (280M affected) involves serotonergic/noradrenergic deficit, HPA dysregulation, neuroinflammation, and reduced BDNF neuroplasticity; SSRIs/SNRIs are first-line; ketamine (IV racemic or nasal esketamine) is the fastest-acting approved antidepressant.

Entry Metadata

FieldValue
IDmajor-depressive-disorder
NameMajor Depressive Disorder
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toSerotonin connects-toNorepinephrine connects-toCortisol connects-toCrh connects-toBdnf targetsBrain connects-toActh connects-toProlactin connects-toTestosterone connects-toEstrogen connects-toThyroid Hormones connects-toProgesterone connects-toMelatonin connects-toVasopressin connects-toLeptin treated-byFluoxetine connects-toHippocampus connects-toNeuron connects-toIl 6 connects-toGlutamate connects-toGut Microbiome connects-toInsomnia Disorder connects-toMicroglia connects-toBipolar Disorder connects-toDopamine connects-toGaba connects-toAstrocyte connects-toOxytocin connects-toMagnesium connects-toSynapse connects-toAdrenal Gland connects-toPhoton connects-toZinc connects-toLarge Intestine connects-toIron connects-toOligodendrocyte connects-toHeart connects-toElectron connects-toVitamin D connects-toStomach connects-toThyroid connects-toTnf Alpha connects-toObesity connects-toReproductive System connects-toNlrp3 Inflammasome connects-toPlatelet connects-toAcetylcholine connects-toT Helper Cell connects-toStroke connects-toType 2 Diabetes connects-toGeneralized Anxiety Disorder connects-toPtsd connects-toNf Kb connects-toAtherosclerosis connects-toVenous Thromboembolism connects-toHeart Failure connects-toCkd connects-toAlcohol Use Disorder connects-toOsteoporosis connects-toAlzheimers Disease connects-toFibromyalgia connects-toNervous System connects-toEndocrine System connects-toImmune System connects-toDigestive System connects-toMusculoskeletal System connects-toRenal System connects-toCardiovascular System connects-toRespiratory System connects-toIntegumentary System connects-toSt Johns Wort connects-toOmega 3 Fatty Acids connects-toToxoplasma Gondii connects-toParkinsons Disease connects-toEpilepsy connects-toMigraine connects-toCardiac Conduction System connects-toRheumatoid Arthritis connects-toIntestinal Epithelium connects-toSchizophrenia connects-toCovid 19 Disease connects-toInflammatory Bowel Disease connects-toIl 1B connects-toSubstance P connects-toNpy connects-toSerotonin Transporter connects-toGlucocorticoid Receptor connects-toIfn Gamma connects-toMtor connects-toEndocannabinoid connects-toCcl2 connects-toNtrk connects-toMu Opioid Receptor connects-toTlr4 connects-toOrexin connects-toGhrelin connects-toXanthine Oxidase connects-toGsk 3B connects-toIl 10 connects-toComplement C3 connects-toMyd88 connects-toNfe2L2 connects-toErk1 2 connects-toAkt connects-toGalectin 3 connects-toJak1 2 connects-toStat3 connects-toCgas Sting connects-toStat1 connects-toFoxo connects-toS100A8 A9 connects-toHif 1Alpha connects-toPik3Ca connects-toAmpk connects-toAutophagy connects-toSrc Kinase connects-toCcr5 connects-toDnmt3A connects-toCxcl12 connects-toIl 33 connects-toIl 17A connects-toArid1A connects-toAdenosine connects-toOsteopontin connects-toAngiotensin Ii connects-toInsulin connects-toAldosterone connects-toVegf connects-toProstaglandins connects-toNitric Oxide connects-toCholesterol connects-toIron connects-toBipolar Disorder connects-toIl 4 connects-toIl 13 connects-toCopper connects-toType I Interferon connects-toAdiponectin connects-toResistin connects-toSocial Anxiety Disorder connects-toPanic Disorder connects-toOpioid Use Disorder connects-toIl 12 connects-toIl 23 connects-toIl 5 connects-toIge connects-toT Cytotoxic Cell connects-toMast Cell connects-toNatural Killer Cell connects-toC5Ar1 connects-toDendritic Cell connects-toHistamine connects-toTslp connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toErythropoietin connects-toPeriostin connects-toSelenium connects-toFactor H connects-toComplement C5 connects-toIodine connects-toSodium connects-toPotassium connects-toCalcium connects-toPhosphorus connects-toChloride connects-toSulfur connects-toNitrogen connects-toOxygen connects-toCarbon connects-toHydrogen connects-toPd 1 connects-toGlp 1 connects-toWnt Beta Catenin connects-toRankl connects-toSmad4 connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toInsulin Receptor connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toFgfr connects-toEpinephrine connects-toRenin connects-toMyostatin connects-toAngiopoietin