Atlas One · Host Biology · Scale 07 — System

Major Depressive Disorder

Major depressive disorder (280M affected) involves serotonergic/noradrenergic deficit, HPA dysregulation, neuroinflammation, and reduced BDNF neuroplasticity; SSRIs/SNRIs are first-line; ketamine (IV racemic or nasal esketamine) is the fastest-acting approved antidepressant.

Also known as: major depressive disorder, MDD, depression, unipolar depression, TRD, treatment-resistant depression, antidepressant, SSRI, SNRI, ketamine depression, esketamine

Scale 07 — SystemScale
draftStatus
2026-06-08Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
major-depressive-disorder

Major Depressive Disorder

Major depressive disorder (280M affected) involves serotonergic/noradrenergic deficit, HPA dysregulation, neuroinflammation, and reduced BDNF neuroplasticity; SSRIs/SNRIs are first-line; ketamine (IV racemic or nasal esketamine) is the fastest-acting approved antidepressant.

Entry Metadata

FieldValue
IDmajor-depressive-disorder
NameMajor Depressive Disorder
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toSerotonin connects-toNorepinephrine connects-toCortisol connects-toCrh connects-toBdnf targetsBrain connects-toActh connects-toProlactin connects-toTestosterone connects-toEstrogen connects-toThyroid Hormones connects-toProgesterone connects-toMelatonin connects-toVasopressin connects-toLeptin treated-byFluoxetine

Sources