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major-depressive-disorder
Major Depressive Disorder
Major depressive disorder (280M affected) involves serotonergic/noradrenergic deficit, HPA dysregulation, neuroinflammation, and reduced BDNF neuroplasticity; SSRIs/SNRIs are first-line; ketamine (IV racemic or nasal esketamine) is the fastest-acting approved antidepressant.
Entry Metadata
| Field | Value |
|---|---|
| ID | major-depressive-disorder |
| Name | Major Depressive Disorder |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toSerotonin
connects-toNorepinephrine
connects-toCortisol
connects-toCrh
connects-toBdnf
targetsBrain
connects-toActh
connects-toProlactin
connects-toTestosterone
connects-toEstrogen
connects-toThyroid Hormones
connects-toProgesterone
connects-toMelatonin
connects-toVasopressin
connects-toLeptin
treated-byFluoxetine
connects-toHippocampus
connects-toNeuron
connects-toIl 6
connects-toGlutamate
connects-toGut Microbiome
connects-toInsomnia Disorder
connects-toMicroglia
connects-toBipolar Disorder
connects-toDopamine
connects-toGaba
connects-toAstrocyte
connects-toOxytocin
connects-toMagnesium
connects-toSynapse
connects-toAdrenal Gland
connects-toPhoton
connects-toZinc
connects-toLarge Intestine
connects-toIron
connects-toOligodendrocyte
connects-toHeart
connects-toElectron
connects-toVitamin D
connects-toStomach
connects-toThyroid
connects-toTnf Alpha
connects-toObesity
connects-toReproductive System
connects-toNlrp3 Inflammasome
connects-toPlatelet
connects-toAcetylcholine
connects-toT Helper Cell
connects-toStroke
connects-toType 2 Diabetes
connects-toGeneralized Anxiety Disorder
connects-toPtsd
connects-toNf Kb
connects-toAtherosclerosis
connects-toVenous Thromboembolism
connects-toHeart Failure
connects-toCkd
connects-toAlcohol Use Disorder
connects-toOsteoporosis
connects-toAlzheimers Disease
connects-toFibromyalgia
connects-toNervous System
connects-toEndocrine System
connects-toImmune System
connects-toDigestive System
connects-toMusculoskeletal System
connects-toRenal System
connects-toCardiovascular System
connects-toRespiratory System
connects-toIntegumentary System
connects-toSt Johns Wort
connects-toOmega 3 Fatty Acids
connects-toToxoplasma Gondii
connects-toParkinsons Disease
connects-toEpilepsy
connects-toMigraine
connects-toCardiac Conduction System
connects-toRheumatoid Arthritis
connects-toIntestinal Epithelium
connects-toSchizophrenia
connects-toCovid 19 Disease
connects-toInflammatory Bowel Disease
connects-toIl 1B
connects-toSubstance P
connects-toNpy
connects-toSerotonin Transporter
connects-toGlucocorticoid Receptor
connects-toIfn Gamma
connects-toMtor
connects-toEndocannabinoid
connects-toCcl2
connects-toNtrk
connects-toMu Opioid Receptor
connects-toTlr4
connects-toOrexin
connects-toGhrelin
connects-toXanthine Oxidase
connects-toGsk 3B
connects-toIl 10
connects-toComplement C3
connects-toMyd88
connects-toNfe2L2
connects-toErk1 2
connects-toAkt
connects-toGalectin 3
connects-toJak1 2
connects-toStat3
connects-toCgas Sting
connects-toStat1
connects-toFoxo
connects-toS100A8 A9
connects-toHif 1Alpha
connects-toPik3Ca
connects-toAmpk
connects-toAutophagy
connects-toSrc Kinase
connects-toCcr5
connects-toDnmt3A
connects-toCxcl12
connects-toIl 33
connects-toIl 17A
connects-toArid1A
connects-toAdenosine
connects-toOsteopontin
connects-toAngiotensin Ii
connects-toInsulin
connects-toAldosterone
connects-toVegf
connects-toProstaglandins
connects-toNitric Oxide
connects-toCholesterol
connects-toIron
connects-toBipolar Disorder
connects-toIl 4
connects-toIl 13
connects-toCopper
connects-toType I Interferon
connects-toAdiponectin
connects-toResistin
connects-toSocial Anxiety Disorder
connects-toPanic Disorder
connects-toOpioid Use Disorder
connects-toIl 12
connects-toIl 23
connects-toIl 5
connects-toIge
connects-toT Cytotoxic Cell
connects-toMast Cell
connects-toNatural Killer Cell
connects-toC5Ar1
connects-toDendritic Cell
connects-toHistamine
connects-toTslp
connects-toBradykinin
connects-toC1 Esterase Inhibitor
connects-toErythropoietin
connects-toPeriostin
connects-toSelenium
connects-toFactor H
connects-toComplement C5
connects-toIodine
connects-toSodium
connects-toPotassium
connects-toCalcium
connects-toPhosphorus
connects-toChloride
connects-toSulfur
connects-toNitrogen
connects-toOxygen
connects-toCarbon
connects-toHydrogen
connects-toPd 1
connects-toGlp 1
connects-toWnt Beta Catenin
connects-toRankl
connects-toSmad4
connects-toIl 2
connects-toFibronectin
connects-toNotch
connects-toIgf 1
connects-toActivin A
connects-toTgf Beta
connects-toCgrp
connects-toCalcitonin
connects-toInsulin Receptor
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toFgfr
connects-toEpinephrine
connects-toRenin
connects-toMyostatin
connects-toAngiopoietin
Sources
- Cipriani A, Furukawa TA, Salanti G, et al. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet. 2018;391(10128):1357-1366. · PubMed 29477251
- Zarate CA Jr, Singh JB, Carlson PJ, et al. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry. 2006;63(8):856-864. · PubMed 16894061
- Duman RS, Aghajanian GK. Synaptic dysfunction in depression: potential therapeutic targets. Science. 2012;338(6103):68-72. · PubMed 23042884