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acth
ACTH
Adrenocorticotropic hormone (corticotropin); 39-aa peptide cleaved from POMC by pituitary corticotrophs. CRH → ACTH → cortisol is the HPA axis effector chain. MC2R/Gs/cAMP/PKA activates adrenal steroidogenesis; circadian peak just before waking; negative feedback via GR.
Entry Metadata
| Field | Value |
|---|---|
| ID | acth |
| Name | ACTH |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Li CH, Dixon JS. Human pituitary growth hormone, XXIX. The primary structure of the hormone: revision. Arch Biochem Biophys. 1956;146(1):233-236. · PubMed 5134365
- Dallman MF, Akana SF, Cascio CS, Darlington DN, Jacobson L, Levin N. Regulation of the hypothalamo-pituitary-adrenal axis during stress: feedback, facilitation and feeding. J Steroid Biochem. 1987;28(1-2):171-179. · PubMed 3116435
- Tsigos C, Chrousos GP. Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J Psychosom Res. 2002;53(4):865-871. · PubMed 12377295