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glucocorticoid-receptor
Glucocorticoid Receptor
Nuclear receptor (NR3C1) mediating cortisol and synthetic glucocorticoid responses. Cytoplasmic until ligand-bound → nuclear translocation → GRE transactivation and NF-κB/AP-1 transrepression → anti-inflammatory gene program. Therapeutic target in asthma, IBD, and RA.
Entry Metadata
| Field | Value |
|---|---|
| ID | glucocorticoid-receptor |
| Name | Glucocorticoid Receptor |
| Status | draft |
| Last reviewed | 2026-06-05 |
| Atlas | 01-human |
| Scale | 03-molecular |
| Gene Symbol | NR3C1 |
| Uniprot | P04150 |
Cross-Atlas Connections
Sources
- Hollenberg SM, Weinberger C, Ong ES, et al. Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature. 1985;318(6047):635-41. · PubMed 2867473
- Cato ACB, Wade E. Molecular mechanisms of anti-inflammatory action of glucocorticoids. BioEssays. 1996;18(5):371-8. · PubMed 8639162
- Rhen T, Cidlowski JA. Antiinflammatory action of glucocorticoids — new mechanisms for old drugs. N Engl J Med. 2005;353(16):1711-23. · PubMed 16236742
- Barnes PJ. How corticosteroids control inflammation: quintiles prize lecture 2005. Br J Pharmacol. 2006;148(3):245-54. · PubMed 16604091